Document Detail

Beta-1-selectivity is not essential to achieve therapeutic efficacy with beta-blockade therapy for idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  7614494     Owner:  NLM     Status:  MEDLINE    
This study investigated the therapeutic efficacy of two different beta-blockers, metoprolol (beta 1-selective) and nipradilol (nonselective) for the treatment of idiopathic dilated cardiomyopathy (DCM). The New York Heart Association functional class improved in the metoprolol group (n = 9) and the nipradilol group (n = 9), but not in the control group who received conventional therapy (n = 8). The left ventricular ejection fraction increased in both the beta-blocker groups (p < 0.01, p < 0.05). Lymphocyte beta-adrenoceptors were upregulated in the nipradilol group (p < 0.01). Cardiac events were less common in both the beta-blocker groups than in the control group (both p < 0.05). Thus, nipradilol improved symptoms and cardiac function with a favorable effect on sympathoneuronal activity as well as metoprolol in patients with DCM. Therefore, beta 1-selectivity is not essential to achieve therapeutic efficacy with beta-blockade therapy for DCM.
T Yoshikawa; S Handa; M Akaishi; H Mitamura; S Ogawa
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiology     Volume:  86     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-24     Completed Date:  1995-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  217-23     Citation Subset:  IM    
Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Cardiomyopathy, Dilated / drug therapy*,  metabolism,  radionuclide imaging
Confounding Factors (Epidemiology)
Coronary Angiography
Lymphocytes / drug effects,  metabolism
Metoprolol / therapeutic use*
Middle Aged
Propanolamines / therapeutic use*
Radionuclide Ventriculography
Receptors, Adrenergic, beta / drug effects*
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 0/Receptors, Adrenergic, beta; 37350-58-6/Metoprolol; 81486-22-8/K 351

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