| Beta 1-integrins on melanoma clones regulate the interaction with autologous cytolytic T-cell clones. | |
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MedLine Citation:
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PMID: 1280157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumor clones isolated from the same subcutaneous metastatic lesion of a melanoma patient were used to investigate the potential role of beta 1-integrins (VLA) in the lysability of neoplastic cells by autologous CD3+, WT31+, CD8+ cytotoxic T-cell clones. Phenotypic analysis of melanoma clones for expression of VLA molecules revealed a subset of clones with high expression of VLA-2, VLA-5, and VLA-6. This subset was also characterized by increased susceptibility to lysis by tumor-specific and nonspecific cytotoxic T-lymphocytes from either TILs or PBLs. Blocking assays with monoclonal antibodies indicated that anti-VLA-2, -5, and -6 antibodies could significantly reduce the lysis of VLA-2+, VLA-5+, and VLA-6+ melanoma clones by either specific and nonspecific CTLs. By contrast, no inhibition was seen on lysis of VLA-2-, VLA-5-, and VLA-6-negative tumor cells. These data indicate that expression of some beta 1-integrins on human melanoma can influence the specific and nonspecific T-cell-mediated recognition of neoplastic cells. |
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Authors:
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A Anichini; R Mortarini; G Parmiani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of immunotherapy : official journal of the Society for Biological Therapy Volume: 12 ISSN: 1053-8550 ISO Abbreviation: J. Immunother. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-12-30 Completed Date: 1992-12-30 Revised Date: 2008-03-18 |
Medline Journal Info:
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Nlm Unique ID: 9102704 Medline TA: J Immunother (1991) Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 183-6 Citation Subset: IM |
Affiliation:
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Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD29 Antigens, CD3 / immunology Antigens, CD8 / immunology Clone Cells Cytotoxicity, Immunologic / immunology Humans Integrins / immunology* Melanoma / immunology* Receptors, Fibronectin / immunology* Receptors, Very Late Antigen / immunology* T-Lymphocytes, Cytotoxic / drug effects, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD29; 0/Antigens, CD3; 0/Antigens, CD8; 0/Integrins; 0/Receptors, Fibronectin; 0/Receptors, Very Late Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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