Document Detail

Beta 1-blockade and acute coronary ischemia. Possible role of platelets.
MedLine Citation:
PMID:  1959217     Owner:  NLM     Status:  MEDLINE    
Although the benefit of beta-adrenergic blocking agents in acute coronary ischemia has been well documented, it is unclear whether the responsible mechanisms include the modification of platelet function. In recent studies, metoprolol appeared to reduce the total number and duration of episodes of silent ischemia in patients with stable coronary artery disease throughout the day. This effect was not associated with a change in baseline or circadian variability of the platelet aggregability. Since the treatment caused significant decreases in heart rate and blood pressure, the drug effect is more likely to be based on reduction of myocardial oxygen demand. Metoprolol, however, prevented a platelet aggregability increase and intracellular cAMP decrease during exercise stress testing in patients with stable angina pectoris. We speculate that this effect of beta 1-adrenergic blockade may be due to hemodynamic and neurohormonal changes, or possibly also to an increase in synthesis or release of platelet inhibiting substances.
K Winther; S N Willich
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Circulation     Volume:  84     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-01-07     Completed Date:  1992-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  VI68-71     Citation Subset:  AIM; IM    
Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Acute Disease
Blood Platelets / drug effects*,  physiology
Coronary Disease / drug therapy*
Metoprolol / pharmacology,  therapeutic use*
Reg. No./Substance:

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