Document Detail


Beryllium disease screening in the ceramics industry. Blood lymphocyte test performance and exposure-disease relations.
MedLine Citation:
PMID:  8455096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We identified nine new cases of biopsy-confirmed chronic beryllium disease among 505 employees and ex-employees in a company that had manufactured beryllia ceramics from 1958 through 1975. Of tests commonly used in medical surveillance, only a confirmed blood beryllium lymphocyte transformation test had a high positive predictive value for beryllium disease (100%). However, two beryllium disease cases had either a normal or inconsistently abnormal blood test and were identified for diagnostic workup by abnormal chest radiograph. The only risk factor for beryllium disease was beryllium exposure; smoking or allergic history did not affect risk. Degree of beryllium exposure was associated with disease rates, which ranged from 2.9% to 15.8% for beryllia-exposed subgroups. One case of beryllium disease occurred in a "dust-disturber" who did not report past beryllium exposure and who began employment 8 years after commercial beryllia production had stopped. Our data support efforts to prevent beryllium disease by lowering beryllium exposures and to identify subclinical and early disease by broad-based medical surveillance using the blood beryllium lymphocyte test and chest radiograph in beryllium-using industries.
Authors:
K Kreiss; S Wasserman; M M Mroz; L S Newman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of occupational medicine. : official publication of the Industrial Medical Association     Volume:  35     ISSN:  0096-1736     ISO Abbreviation:  J Occup Med     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-20     Completed Date:  1993-04-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7502807     Medline TA:  J Occup Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-74     Citation Subset:  IM    
Affiliation:
Occupational and Environmental Medicine Division, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Berylliosis / diagnosis,  immunology,  prevention & control*
Beryllium / immunology*
Ceramics / adverse effects*
Environmental Monitoring
Female
Humans
Lymphocyte Activation / immunology*
Male
Middle Aged
Occupational Exposure / adverse effects,  prevention & control*
Population Surveillance
Predictive Value of Tests
Risk Factors
Grant Support
ID/Acronym/Agency:
ES 00173/ES/NIEHS NIH HHS; R01 ES04843/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Ceramics; 7440-41-7/Beryllium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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