| Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. | |
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MedLine Citation:
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PMID: 20121200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biodirected fractionation is used to identify the active inhibitory constituents in berries for esophageal cancer in rats. The present study was undertaken to determine if ellagitannins contribute to the chemopreventive activity of an alcohol/water-insoluble (residue) fraction of berries. Rats consumed diets containing residue fractions of three berry types, that is, black raspberries (BRBs), strawberries (STRWs), and blueberries (BBs), that differ in their content of ellagitannins in the order BRB > STRW > BB. Animals were fed residue diets beginning 2 weeks before treatment with the esophageal carcinogen N-nitrosomethylbenzylamine (NMBA) and throughout the 30-week bioassay. Residue fractions from all three berry types were about equally effective in reducing NMBA tumorigenesis in the rat esophagus irrespective of their ellagitannin content (0.01-0.62 g/kg of diet). These results suggest that the ellagitannins may not be responsible for the chemopreventive effects of the alcohol/water-insoluble fraction of berries. |
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Authors:
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Li-Shu Wang; Stephen Hecht; Steven Carmella; Claire Seguin; Claudio Rocha; Nanxiong Yu; Kristen Stoner; Steven Chiu; Gary Stoner |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-08-31 Revised Date: 2011-12-07 |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 3992-5 Citation Subset: IM |
Affiliation:
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The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43240, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blueberry Plant / chemistry* Disease Models, Animal Esophageal Neoplasms / drug therapy, prevention & control* Fruit / chemistry* Humans Hydrolyzable Tannins / administration & dosage* Male Plant Extracts / administration & dosage* Random Allocation Rats Rats, Sprague-Dawley Rosaceae / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA103180-06/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hydrolyzable Tannins; 0/Plant Extracts |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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