Document Detail


The Bergen Blood Pressure Study: blood pressure changes, target organ damage and mortality in subjects with high and low blood pressure over 27 years.
MedLine Citation:
PMID:  8180723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Based on the Bergen population screening in 1963-64, 344 married couples (688 subjects), then aged 30-69 years, were included for studies in families with a history of hypertension or normotension. In 1990 430 subjects were available to a follow-up examination. The present paper describes 27-year mortality, blood pressure (BP) changes, cardiovascular disease and target organ damage in this population. In males who were hypertensive by the 1963-64 screening BP, the all-cause 27-year mortality was three times higher than in initially normotensive males (p < 0.05). From 1963-64 to 1990, the systolic BP was generally increased, whereas the diastolic BP was decreased in initially hypertensive and increased in initially normotensive subjects. In subjects who were hypertensive in 1963-64, the relative risk of hypertension in 1990 was more than seven times higher than in initially normotensive subjects (p < 0.05), cardiovascular events were reported more often (p < 0.001), and the mean electrocardiographic left ventricular voltage was higher (p < 0.01). Proteinuria was more frequent in initially hypertensive than normotensive males (p < 0.01). In summary, hypertension defined by a single BP recording at the 1963-64 screening was a risk factor for hypertension, cardiovascular morbidity and, for males, all-cause mortality 27 years later. With respect to offspring studies, our findings substantiate the classification of hypertensive and normotensive families. From 1963-64 to 1990, the BP status had changed in several couples, and the long observation period seems mandatory if a reliable definition of the family history of hypertension or normotension is to be obtained.
Authors:
R Mo; P Omvik; P Lund-Johansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  2     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1994-06-15     Completed Date:  1994-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  113-23     Citation Subset:  IM    
Affiliation:
Department for Heart Diseases, University of Bergen, School of Medicine, Haukeland Hospital, Norway.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology*
Cardiovascular Diseases / physiopathology
Female
Heart Rate / physiology
Humans
Hypertension / drug therapy,  mortality*,  physiopathology*
Hypertrophy, Left Ventricular / physiopathology
Male
Middle Aged
Proteinuria / physiopathology
Risk Factors
Time Factors
Chemical
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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