| Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. | |
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MedLine Citation:
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PMID: 22027215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Berberine (BBR) has recently been shown to improve insulin sensitivity in rodent models of insulin resistance. Although this effect was explained partly through an observed activation of AMP-activated protein kinase (AMPK), the upstream and downstream mediators of this phenotype were not explored. Here, we show that BBR supplementation reverts mitochondrial dysfunction induced by High Fat Diet (HFD) and hyperglycemia in skeletal muscle, in part due to an increase in mitochondrial biogenesis. Furthermore, we observe that the prevention of mitochondrial dysfunction by BBR, the increase in mitochondrial biogenesis, as well as BBR-induced AMPK activation, are blocked in cells in which SIRT1 has been knocked-down. Taken together, these data reveal an important role for SIRT1 and mitochondrial biogenesis in the preventive effects of BBR on diet-induced insulin resistance. |
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Authors:
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Ana P Gomes; Filipe V Duarte; Patricia Nunes; Basil P Hubbard; João S Teodoro; Ana T Varela; John G Jones; David A Sinclair; Carlos M Palmeira; Anabela P Rolo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-10-17 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1822 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-02 Completed Date: 2012-07-10 Revised Date: 2013-03-01 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 185-95 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Center for Neurosciences and Cell Biology, Department of Life Sciences, University of Coimbra 3004-517 Coimbra, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AMP-Activated Protein Kinases
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metabolism Animals Berberine / pharmacology* Biogenesis* Cell Line Diet, High-Fat* Glucose / metabolism Hormones / metabolism Hyperglycemia / metabolism Insulin Resistance Male Mice Mitochondria / drug effects*, metabolism Mitochondria, Muscle / drug effects*, metabolism Muscle, Skeletal / drug effects, metabolism Myoblasts / drug effects, metabolism NAD / metabolism Obesity / metabolism Phosphorylation / drug effects Rats Rats, Sprague-Dawley Sirtuin 1 / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG019719/AG/NIA NIH HHS; R01 AG028730/AG/NIA NIH HHS; R0I AG 028730/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 2086-83-1/Berberine; 50-99-7/Glucose; 53-84-9/NAD; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 3.5.1.-/Sirt1 protein, mouse; EC 3.5.1.-/Sirtuin 1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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