Document Detail

Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts.
MedLine Citation:
PMID:  18164189     Owner:  NLM     Status:  MEDLINE    
Matrix metalloproteinases (MMPs) induction and type I procollagen reduction in photoaging of the skin due to exposure to ultraviolet (UV) irradiation. Therefore, regulation of these genes has been suggested to be a useful tool to abolish skin aging. In this study, antioxidative plant ingredients used in traditional Chinese medicine, berberine (BBR) was investigated for their capacity to regulate MMP-1 and type I procollagen expression in human dermal fibroblasts. Our results showed that both basal and UV-induced MMP-1 expression was decreased by BBR. On the other hand, type I procollagen expression was dose-dependently increased by it. In addition, UV-induced reduction of type I procollagen expression is recovered by it. Therefore, we suggest that BBR may be a possible candidate for anti-skin aging agent.
Sangmin Kim; Jin Ho Chung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-27
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  15     ISSN:  1618-095X     ISO Abbreviation:  Phytomedicine     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  749-53     Citation Subset:  IM    
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Berberine / pharmacology*
Blotting, Western
Cells, Cultured
Collagen Type I / antagonists & inhibitors*,  metabolism
Enzyme Induction
Fibroblasts / drug effects,  enzymology,  metabolism
Matrix Metalloproteinase 1 / antagonists & inhibitors*,  biosynthesis
Skin / cytology,  drug effects*,  enzymology,  metabolism
Ultraviolet Rays*
Reg. No./Substance:
0/Collagen Type I; 2086-83-1/Berberine; EC Metalloproteinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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