Document Detail

Berberine inhibits HEp-2 cell invasion induced by Chlamydophila pneumoniae infection.
MedLine Citation:
PMID:  22068503     Owner:  NLM     Status:  In-Data-Review    
This study investigated the inhibitory effects of berberine on Chlamydophila (Chlamydia) pneumoniae infection-induced HEp-2 cell invasion and explored the possible mechanisms involved in this process. C. pneumoniae infection resulted in a significant increase in HEp-2 cell invasion when compared with the control cells (P<0.01) in a Matrigel invasion assay. This enhanced cell invasion was strongly suppressed by berberine (50 μM) (P<0.01). In a cell adhesion assay, the infection-induced HEp-2 cell adhesion to Matrigel was also significantly inhibited by berberine (P<0.01). C. pneumoniae infection was found to promote HEp-2 cell migration remarkably (P<0.01), which was markedly suppressed by berberine (P<0.01) in the cell migration assays. There were no statistically significant differences in the expression of matrix metalloproteinase-1 (MMP-1) and MMP-9 in the infected cells and berberine did not change the expression of MMP-1 and MMP-9. These data suggest that berberine inhibits C. pneumoniae infection-induced HEp-2 cell invasion through suppressing HEp-2 cell adhesion and migration, but not through changing the expression of MMP-1 and MMP-9.
Li Jun Zhang; Li Jun Zhang; Wei Quan; Bei Bei Wang; Bing Ling Shen; Teng Teng Zhang; Yi Kang
Related Documents :
18548553 - Continuos ibe fermentation by immobilized growing clostridium beijerinckii cells in a s...
4717513 - Bacterial metabolism of 3-hydroxy-3-methylglutaric acid.
24802273 - Tualang honey improves human corneal epithelial progenitor cell migration and cellular ...
Publication Detail:
Type:  Journal Article     Date:  2011-11-09
Journal Detail:
Title:  Journal of microbiology (Seoul, Korea)     Volume:  49     ISSN:  1976-3794     ISO Abbreviation:  J. Microbiol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9703165     Medline TA:  J Microbiol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  834-40     Citation Subset:  IM    
Department of Pathophysiology, Basic Medical School of Tianjin Medical University, Tianjin, 300070, P. R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Functional analysis of SGR4635-induced enhancement of pigmented antibiotic production in Streptomyce...
Next Document:  Interaction of Acinetobacter baumannii 19606 and 1656-2 with Acanthamoeba castellanii.