| Berberine inhibits HEp-2 cell invasion induced by Chlamydophila pneumoniae infection. | |
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MedLine Citation:
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PMID: 22068503 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study investigated the inhibitory effects of berberine on Chlamydophila (Chlamydia) pneumoniae infection-induced HEp-2 cell invasion and explored the possible mechanisms involved in this process. C. pneumoniae infection resulted in a significant increase in HEp-2 cell invasion when compared with the control cells (P<0.01) in a Matrigel invasion assay. This enhanced cell invasion was strongly suppressed by berberine (50 μM) (P<0.01). In a cell adhesion assay, the infection-induced HEp-2 cell adhesion to Matrigel was also significantly inhibited by berberine (P<0.01). C. pneumoniae infection was found to promote HEp-2 cell migration remarkably (P<0.01), which was markedly suppressed by berberine (P<0.01) in the cell migration assays. There were no statistically significant differences in the expression of matrix metalloproteinase-1 (MMP-1) and MMP-9 in the infected cells and berberine did not change the expression of MMP-1 and MMP-9. These data suggest that berberine inhibits C. pneumoniae infection-induced HEp-2 cell invasion through suppressing HEp-2 cell adhesion and migration, but not through changing the expression of MMP-1 and MMP-9. |
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Authors:
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Li Jun Zhang; Li Jun Zhang; Wei Quan; Bei Bei Wang; Bing Ling Shen; Teng Teng Zhang; Yi Kang |
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Publication Detail:
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Type: Journal Article Date: 2011-11-09 |
Journal Detail:
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Title: Journal of microbiology (Seoul, Korea) Volume: 49 ISSN: 1976-3794 ISO Abbreviation: J. Microbiol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9703165 Medline TA: J Microbiol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 834-40 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Basic Medical School of Tianjin Medical University, Tianjin, 300070, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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