Document Detail


Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity.
MedLine Citation:
PMID:  19176354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AMP-activated protein kinase (AMPK) plays an important role in regulating whole body energy homeostasis. Recently, it has been demonstrated that berberine (BBR) exerts antiobesity and antidiabetic effects in obese and diabetic rodent models through the activation of AMPK in peripheral tissues. Here we show that BBR improves lipid dysregulation and fatty liver in obese mice through central and peripheral actions. In obese db/db and ob/ob mice, BBR treatment reduced liver weight, hepatic and plasma triglyceride, and cholesterol contents. In the liver and muscle of db/db mice, BBR promoted AMPK activity and fatty acid oxidation and changed expression of genes involved in lipid metabolism. Additionally, intracerebroventricular administration of BBR decreased the level of malonyl-CoA and stimulated the expression of fatty acid oxidation genes in skeletal muscle. Together, these data suggest that BBR would improve fatty liver in obese subjects, which is probably mediated not only by peripheral AMPK activation but also by neural signaling from the central nervous system.
Authors:
Woo Sik Kim; Yun Sok Lee; Seung Hun Cha; Hyun Woo Jeong; Sung Sik Choe; Mi-Ran Lee; Goo Taeg Oh; Hye-Sun Park; Ki-Up Lee; M Daniel Lane; Jae Bum Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-27
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  296     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-25     Completed Date:  2009-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E812-9     Citation Subset:  IM    
Affiliation:
Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University, San 56-1, Sillim-Dong, Kwanak-Gu, Seoul 151-742, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adenylate Kinase / metabolism*
Animals
Antilipemic Agents / pharmacology,  therapeutic use
Berberine / pharmacology*,  therapeutic use*
Cells, Cultured
Diabetes Mellitus, Experimental / complications,  drug therapy,  genetics
Drug Evaluation, Preclinical
Dyslipidemias / complications,  drug therapy*,  genetics,  metabolism
Enzyme Activation / drug effects
Fatty Acids / metabolism
Fatty Liver / complications,  drug therapy
Gene Expression Regulation / drug effects
Lipid Metabolism / drug effects,  genetics
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Obesity / complications,  drug therapy*,  genetics,  metabolism
Oxidation-Reduction / drug effects
Receptors, Leptin / genetics
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Fatty Acids; 0/Receptors, Leptin; 2086-83-1/Berberine; EC 2.7.4.3/Adenylate Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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