| Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. | |
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MedLine Citation:
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PMID: 20646989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Berberine (BBR) was previously found to have beneficial effects on renal injury in experimental diabetic rats. However, the mechanisms underlying the effects are not fully understood. Sphingosine kinase-Sphingosine 1-phosphate (SphK-S1P) signaling pathway has been implicated in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to investigate the effects of BBR on renal injury and the activation of SphK-S1P signaling pathway in alloxan-induced diabetic mice with nephropathy. Alloxan-induced diabetic mice were treated orally with BBR (300 mg/kg/day) or vehicle for 12 weeks. BBR inhibited the increases in fasting blood glucose, kidney/body weight ratio, blood urea nitrogen, serum creatinine and 24-h albuminuria in diabetic mice. It also prevented renal hypertrophy, TGF-beta1 synthesis, FN and Col IV accumulation. Moreover, BBR down-regulated the elevated staining, activity and levels of mRNA and protein of SphK1, and S1P production as well. These findings suggest that the inhibitory effect of BBR on the activation of SphK-S1P signaling pathway in diabetic mouse kidney is a novel mechanism by which BBR partly exerts renoprotective effects on DN. |
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Authors:
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Tian Lan; Xiaoyan Shen; Peiqing Liu; Weihua Liu; Suowen Xu; Xi Xie; Qin Jiang; Wenyuan Li; Heqing Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-18 |
Journal Detail:
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Title: Archives of biochemistry and biophysics Volume: 502 ISSN: 1096-0384 ISO Abbreviation: Arch. Biochem. Biophys. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372430 Medline TA: Arch Biochem Biophys Country: United States |
Other Details:
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Languages: eng Pagination: 112-20 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Sun Yat-sen University, Guangzhou, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria
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pathology Animals Berberine / pharmacology* Diabetes Mellitus / pathology Diabetes Mellitus, Experimental / pathology Diabetic Nephropathies / pathology Glucose / metabolism Kidney / metabolism, pathology* Lysophospholipids Male Mice Mice, Inbred C57BL Phosphotransferases (Alcohol Group Acceptor) Random Allocation Signal Transduction / drug effects Sphingosine / analogs & derivatives Transforming Growth Factor beta1 |
| Chemical | |
Reg. No./Substance:
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0/Lysophospholipids; 0/Transforming Growth Factor beta1; 123-78-4/Sphingosine; 2086-83-1/Berberine; 26993-30-6/sphingosine 1-phosphate; 50-99-7/Glucose; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.-/sphingosine kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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