| Berberine alleviates ischemic arrhythmias via recovering depressed I(to) and I(Ca) currents in diabetic rats. | |
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MedLine Citation:
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PMID: 22188769 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The present study was designed to elucidate the potential mechanism underlying that berberine suppressed ischemic arrhythmias in a rat model of diabetes mellitus (DM). Streptozotocin (STZ)-induced diabetic rats were subjected to ischemia by the occlusion of left anterior descending (LAD) coronary artery. Berberine was orally administered for 7 days before ischemic injury in diabetic rats. Whole-cell patch-clamp was performed to measure the transient outward K(+) current (I(to)) and L-type Ca(2+) current (I(Ca)). Results showed that oral administration of berberine (100mg/kg) attenuated ischemia-induced arrhythmias in diabetic rats. Berberine significantly shortened the prolonged QTc interval from 214±6ms to 189±5ms in ischemic diabetic rats, and also restored the diminished I(to) and I(Ca) current densities in the same animal model rats. In conclusion, the ability of berberine to protect diabetic rats against cardiac arrhythmias makes it possible to be a prospective therapeutic agent in clinical management of cardiac disease secondary to diabetes. |
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Authors:
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Li-Hong Wang; Xue-Lian Li; Qiang Li; Ying Fu; Hai-Jing Yu; Yu-Qian Sun; Li Zhang; Hong-Li Shan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: - ISSN: 1618-095X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Endocrinology, The Second affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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