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BerEP4-negative basal cell carcinoma on the palm: case report and review of the literature.
MedLine Citation:
PMID:  20629842     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Only 10 cases of patients with isolated basal cell carcinoma (BCC) of the palms and soles have been published. We describe a patient with an isolated basal cell carcinoma of the palm. Our patient denied injury and exposure to noxious agents; he did not have basal cell nevus syndrome. The tumor was negative for EpCAM as determined by BerEP4 immunohistochemistry, although EpCAM expression usually is seen in BCC in more conventional locations. Because the tumor cells were connected to secretory eccrine glands, we speculate that BCC of the palm originates from common progenitor cells of eccrine glands or epidermal stem cells. We review the literature on these rare BCC in atypical anatomical regions, and discuss the cellular origin of BCC in such locations.
Authors:
Anna Mleczko; Ingolf Franke; Anna Pokrywka; Harald Gollnick; Martin Leverkus
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG     Volume:  9     ISSN:  1610-0387     ISO Abbreviation:  J Dtsch Dermatol Ges     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101164708     Medline TA:  J Dtsch Dermatol Ges     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  140-3     Citation Subset:  IM    
Copyright Information:
© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.
Affiliation:
Department of Dermatology and Venereology, University of Magdeburg, Germany Department of Dermatology, Venereology and Allergy, Medical Faculty of Mannheim of the University of Heidelberg, Germany.
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