Document Detail

Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin.
MedLine Citation:
PMID:  10971697     Owner:  NLM     Status:  MEDLINE    
AIMS: Seventy-five skin tumours were studied to investigate the value of immunohistochemistry in differentiating basal cell, squamous cell and basosquamous carcinomas of the skin. METHODS AND RESULTS: Archived paraffin-embedded tissue samples of basal cell carcinomas (n = 39), squamous cell carcinomas (n = 23) and basosquamous carcinomas (n = 13) were stained immunohistochemically using a panel of antibodies. All of the basal cell carcinomas stained positively for Ber EP4, in contrast to the group of squamous cell carcinomas, that showed no staining. Basosquamous carcinomas all showed at least some areas of Ber EP4 positivity. None of the basal cell carcinomas, but most of the squamous cell carcinomas (22 of 23) expressed epithelial membrane antigen (EMA). Only one of the basosquamous carcinomas expressed EMA positivity focally. CAM 5.2, carcinoembryonic antigen (CEA) and 34betaE12 antibodies lacked specificity in relation to the different tumour types. CONCLUSION: Distinction of basal and squamous cell carcinomas of the skin can be readily achieved with routine immunohistochemistry using Ber EP4 and EMA. Identification of basosquamous carcinoma is also facilitated with this method.
T W Beer; P Shepherd; J M Theaker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  37     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-02     Completed Date:  2000-10-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  218-23     Citation Subset:  IM    
Department of Histopathology, Royal Haslar Hospital, Gosport, UK.
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MeSH Terms
Aged, 80 and over
Antigens, Surface / analysis*
Biological Markers
Carcinoembryonic Antigen / analysis
Carcinoma / metabolism,  pathology*
Carcinoma, Basal Cell / metabolism,  pathology
Carcinoma, Basosquamous / metabolism,  pathology
Carcinoma, Squamous Cell / metabolism,  pathology
Diagnosis, Differential
Keratins / analysis
Middle Aged
Mucin-1 / analysis*
Skin Neoplasms / metabolism,  pathology*
Tumor Markers, Biological*
Reg. No./Substance:
0/Antigens, Surface; 0/Biological Markers; 0/CAM 5.2 antigen; 0/Carcinoembryonic Antigen; 0/Mucin-1; 0/Tumor Markers, Biological; 0/human epithelial antigen-125; 68238-35-7/Keratins

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