Document Detail

Bepridil inhibits sub-acute phase of atrial electrical remodeling in canine rapid atrial stimulation model.
MedLine Citation:
PMID:  16434817     Owner:  NLM     Status:  MEDLINE    
Background The effect of bepridil, a multichannel blocker, on atrial electrical remodeling was evaluated in a canine rapid atrial stimulation model. Methods and Results In 10 beagle dogs, the right atrial appendage (RAA) was paced at 400 beats/min for 2 weeks. The atrial electrophysiological parameters, including effective refractory period (AERP), were evaluated at three atrial sites: RAA, the right atrium close to the inferior vena cava (IVC) and the left atrium (LA), during the time course of rapid pacing. Five of the dogs were given bepridil (10 mg . kg (-1) . day(-1) po). In the control group, AERP was significantly shortened at all atrial sites and the AERP shortening (DeltaAERP) was larger for the RAA and LA than at the IVC site (p<0.05). In the bepridil group, DeltaAERP was smaller than that of the controls at all atrial sites, and the AERP started to return slowly to the pre-pacing level in the second week, regardless of the continuation of rapid pacing. Conclusions In a canine rapid atrial stimulation model, bepridil suppressed AERP shortening. Bepridil might have a reverse electrical remodeling effect, at least for AERP shortening, because it showed slow recovery of AERP in the subacute phase of rapid atrial pacing. (Circ J 2006; 70: 206 - 213).
Daisuke Sato; Shinichi Niwano; Ryuta Imaki; Yoshihiko Masaki; Sae Sasaki; Masaru Yuge; Shoji Hirasawa; Takeshi Sasaki; Masahiko Moriguchi; Hiroe Niwano; Hirokuni Yoshimura; Tohru Izumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  70     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-25     Completed Date:  2006-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  206-13     Citation Subset:  IM    
Departments of Angiocardiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 228-8555, Japan.
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MeSH Terms
Bepridil / pharmacology*
Calcium Channel Blockers / pharmacology*
Heart Atria / physiopathology
Heart Conduction System / physiopathology*
Models, Cardiovascular*
Myocardial Contraction / drug effects*
Reg. No./Substance:
0/Calcium Channel Blockers; 64706-54-3/Bepridil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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