Document Detail

Bepridil is effective and improves QOL in multidrug-resistant paroxysmal atrial fibrillation.
MedLine Citation:
PMID:  22914308     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Efficacy and safety of long-term administration of bepridil as a rhythm and rate controller were comprehensively evaluated in patients with multidrug-resistant paroxysmal atrial fibrillation (PAF). METHODS: A retrospective survey from 1992 to 2006 was conducted on 62 multidrug-resistant PAF patients treated with bepridil from 480 consecutive PAF patients. In addition, a 5-year follow-up study was conducted on 28 of the 62 patients, being continued from 2006 to 2011. The efficacy of bepridil, improvement in symptoms including patients' quality of life (QOL), ECGs, hemodynamics, and its adverse effects were examined. RESULTS: In the retrospective survey, 127 ± 44 mg of bepridil was given for 21 ± 18 months and 40.3% maintained sinus rhythm. Reductions in the frequency and the duration of each episode of PAF and improvement in symptoms were seen in 48.4, 50.0 and 93.5% of the 62 patients, respectively. Reversible torsades de pointes (TdP) occurred in two aged women. Bradycardia and hepatic dysfunction developed in one patient each. In the follow-up study, 100 ± 20 mg of bepridil was given. Sinus rhythm was maintained in 13 patients. Although the occurrences of PAF continued in 14 patients, their symptoms and QOL were improved. No adverse effects were noted in all 28 patients of the follow-up study. CONCLUSIONS: Bepridil was effective in rhythm control in 40% of PAF patients resistant to other antiarrhythmics. Even in those who had failed to maintain sinus rhythm, continued administration of low-dose bepridil improved their symptoms and QOL with few adverse effects. Bepridil is worth returning to use.
Atsushi Shamoto; Akiko Chishaki; Miyuki Tsuchihashi-Makaya; Hiroaki Chishaki; Masao Takemoto; Yasushi Mukai; Shujiro Inoue; Kenji Sunagawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-20
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  -     ISSN:  1558-2035     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aDepartment of Preventive Medicine bDepartment of Health Sciences, Kyushu University Graduate School of Medical Sciences cDepartment of Cardiovascular Medicine, Kyushu University Hospital, Maidashi, Higashi-ku, Fukuoka dDepartment of Nursing, Kitasato University, Kanagawa eCollege of Healthcare Management, Takayanagi, Setaka-chou, Miyama, Fukuoka, Japan.
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