Document Detail

Benzylpenicillin migrates irreversibly into human erythrocytes.
MedLine Citation:
PMID:  599085     Owner:  NLM     Status:  MEDLINE    
Benzylpenicillin, 5.2% 14C-enriched, was incubated with human whole blood. The erythrocyte component was washed and exhaustively dialyzed and found to contain 6.3% of the original radioactivity. None of the penicillin was found to bind to the cell membrane. Dialysis of the cell contents indicated that none of the penicillin binds irreversibly to the proteins within the cell. Infrared examination of the contents of the cell leads to the conclusion that benzylpenicillin (a monovalent anion) enters the erythrocyte and is hydrolyzed to benzylpenicilloic acid (a divalent anion). This structural change prevents the antibiotic from migrating out of the cell.
E S Wagner; B Lindley; M Talbert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  30     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-03-21     Completed Date:  1978-03-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1115-8     Citation Subset:  IM    
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MeSH Terms
Chemical Phenomena
Erythrocytes / metabolism*
Penicillin G / blood*
Spectrophotometry, Infrared
Reg. No./Substance:
61-33-6/Penicillin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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