Document Detail

Benzylmercapturic acid is superior to hippuric acid and o-cresol as a urinary marker of occupational exposure to toluene.
MedLine Citation:
PMID:  14757321     Owner:  NLM     Status:  MEDLINE    
The present study was initiated to examine whether urinary benzylmercapturic acid (or N-acetyl-S-benzyl cysteine, BMA), a mercapturate metabolite of toluene, increases in relation to the intensity of toluene exposure, and whether this metabolite is a better marker of occupational exposure to toluene than two traditional markers, hippuric acid and o-cresol. Accordingly, end-of-shift urine samples were collected from 122 printers and 30 office clerks (all men) in the second half of a working week. Solvent (toluene) exposure of the day (8 h) was monitored by means of diffusive sampling. Quantitative relation with toluene showed that BMA had a greater correlation coefficient with toluene (r = 0.7) than hippuric acid (r = 0.6) or o-cresol (r = 0.6). The levels in the urine of the non-exposed control subjects were below the detection limit of 0.2 microg/l for BMA, whereas it was at substantial levels for hippuric acid and o-cresol (239 mg/l and 32 microg/l as a geometric mean, respectively). Thus, BMA, hippuric acid and o-cresol could separate the exposed from the non-exposed when toluene was at < 1, 50 and 3 ppm, respectively. Overall, therefore, it appeared reasonable to conclude that BMA is superior to hippuric acid and o-cresol as a marker of occupational exposure to toluene.
O Inoue; E Kanno; K Kasai; H Ukai; S Okamoto; M Ikeda
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  147     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  177-86     Citation Subset:  IM    
Tohoku Rosai Hospital, Sendai 981-0911, Japan.
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MeSH Terms
Acetylcysteine / analogs & derivatives*,  urine*
Biological Markers
Chromatography, High Pressure Liquid
Cresols / urine*
Dose-Response Relationship, Drug
Hippurates / urine*
Indicators and Reagents
Occupational Exposure / analysis*
Regression Analysis
Toluene / adverse effects*
Reg. No./Substance:
0/Biological Markers; 0/Cresols; 0/Hippurates; 0/Indicators and Reagents; 0/Solvents; 108-88-3/Toluene; 19542-77-9/S-benzyl-N-acetyl-L-cysteine; 495-69-2/hippuric acid; 616-91-1/Acetylcysteine; 95-48-7/2-cresol

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