| Benzylmercapturic acid is superior to hippuric acid and o-cresol as a urinary marker of occupational exposure to toluene. | |
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MedLine Citation:
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PMID: 14757321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was initiated to examine whether urinary benzylmercapturic acid (or N-acetyl-S-benzyl cysteine, BMA), a mercapturate metabolite of toluene, increases in relation to the intensity of toluene exposure, and whether this metabolite is a better marker of occupational exposure to toluene than two traditional markers, hippuric acid and o-cresol. Accordingly, end-of-shift urine samples were collected from 122 printers and 30 office clerks (all men) in the second half of a working week. Solvent (toluene) exposure of the day (8 h) was monitored by means of diffusive sampling. Quantitative relation with toluene showed that BMA had a greater correlation coefficient with toluene (r = 0.7) than hippuric acid (r = 0.6) or o-cresol (r = 0.6). The levels in the urine of the non-exposed control subjects were below the detection limit of 0.2 microg/l for BMA, whereas it was at substantial levels for hippuric acid and o-cresol (239 mg/l and 32 microg/l as a geometric mean, respectively). Thus, BMA, hippuric acid and o-cresol could separate the exposed from the non-exposed when toluene was at < 1, 50 and 3 ppm, respectively. Overall, therefore, it appeared reasonable to conclude that BMA is superior to hippuric acid and o-cresol as a marker of occupational exposure to toluene. |
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Authors:
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O Inoue; E Kanno; K Kasai; H Ukai; S Okamoto; M Ikeda |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology letters Volume: 147 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-03 Completed Date: 2004-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 177-86 Citation Subset: IM |
Affiliation:
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Tohoku Rosai Hospital, Sendai 981-0911, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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analogs & derivatives*,
urine* Adult Biological Markers Chromatography, High Pressure Liquid Cresols / urine* Dose-Response Relationship, Drug Female Hippurates / urine* Humans Indicators and Reagents Male Occupational Exposure / analysis* Regression Analysis Solvents Toluene / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cresols; 0/Hippurates; 0/Indicators and Reagents; 0/Solvents; 108-88-3/Toluene; 19542-77-9/S-benzyl-N-acetyl-L-cysteine; 495-69-2/hippuric acid; 616-91-1/Acetylcysteine; 95-48-7/2-cresol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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