Document Detail


Benzylamines: synthesis and evaluation of antimycobacterial properties.
MedLine Citation:
PMID:  6433022     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (19, MIC 10.2 micrograms/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 micrograms/mL), and N-butyl-3,5-difluorobenzylamine (103, MIC 6.4 micrograms/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combinations of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.
Authors:
W R Meindl; E von Angerer; H Schönenberger; G Ruckdeschel
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  27     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-10-03     Completed Date:  1984-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1111-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amines / pharmacology*
Antitubercular Agents / pharmacology*
Benzylamines / chemical synthesis,  pharmacology*
Mycobacterium / drug effects*
Mycobacterium tuberculosis / drug effects*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Amines; 0/Antitubercular Agents; 0/Benzylamines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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