| Benzylamines: synthesis and evaluation of antimycobacterial properties. | |
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MedLine Citation:
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PMID: 6433022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (19, MIC 10.2 micrograms/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 micrograms/mL), and N-butyl-3,5-difluorobenzylamine (103, MIC 6.4 micrograms/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combinations of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra. |
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Authors:
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W R Meindl; E von Angerer; H Schönenberger; G Ruckdeschel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 27 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-10-03 Completed Date: 1984-10-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1111-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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pharmacology* Antitubercular Agents / pharmacology* Benzylamines / chemical synthesis, pharmacology* Mycobacterium / drug effects* Mycobacterium tuberculosis / drug effects* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Antitubercular Agents; 0/Benzylamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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