Document Detail


Benzyl acetate carcinogenicity, metabolism, and disposition in Fischer 344 rats and B6C3F1 mice.
MedLine Citation:
PMID:  4060166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carcinogenesis studies of benzyl acetate (a fragrance and flavoring agent) were conducted in F344 rats and B6C3F1 mice. The chemical was given in corn oil by gavage once daily, 5 days/week for 103 weeks, to groups of 50 animals of each sex and species. For rats the doses were 0, 250, and 500 mg/kg body weight and for mice the doses were 0, 500, and 1000 mg/kg. Mean body weights of control and dosed rats and mice were not affected adversely by benzyl acetate. The survival of control and low dose female mice was lower than that of the high dose group. A genital tract infection may have contributed to the reduced survival. No other significant difference in survival was observed for dosed rats or mice. Benzyl acetate was absorbed from the gastrointestinal tract of rats and mice, with approximately 90% of the administered dose recovered as various metabolites in the urine within 24 h. The primary metabolite was hippuric acid, with minor amounts of a mercapturic acid, and one or more unidentified metabolites. This capacity for absorption, metabolism, and disposition was unaffected by the amount or number of doses administered. Under the conditions of these studies, benzyl acetate administration was associated with an increased incidence of acinar cell adenoma of the exocrine pancreas in male F344/N rats. No evidence of carcinogenicity was found for female F344/N rats. For male and female B6C3F1 mice there was evidence of carcinogenicity, in that benzyl acetate caused an increased incidence of hepatocellular neoplasms (particularly adenomas) and squamous cell neoplasms of the forestomach.
Authors:
K M Abdo; J E Huff; J K Haseman; G A Boorman; S L Eustis; H B Matthews; L T Burka; J D Prejean; R B Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  37     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-05     Completed Date:  1985-12-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  159-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Oral
Animals
Benzyl Compounds / metabolism*,  toxicity
Body Weight / drug effects
Carbon Radioisotopes
Carcinogens*
Female
Injections, Intravenous
Liver Neoplasms / chemically induced
Male
Mice
Pancreatic Neoplasms / chemically induced
Rats
Rats, Inbred F344
Sex Factors
Species Specificity
Chemical
Reg. No./Substance:
0/Benzyl Compounds; 0/Carbon Radioisotopes; 0/Carcinogens; 140-11-4/benzyl acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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