Document Detail


Benzoylalanine: detection and identification of an alanine conjugate with benzoic acid in hyperammonemic patients treated with sodium benzoate.
MedLine Citation:
PMID:  4053389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Urine of four hyperammonemic patients who were treated with large amounts of sodium benzoate were analyzed. Gas chromatographic and gas chromatograph-mass spectrometric analysis showed the presence of large amounts of benzoylalanine in addition to much hippuric acid. Benzoylalanine was identified by comparison with an authentic standard by means of its mass spectrum and the gas chromatographic retention time of its trimethylsilyl derivative. This abnormal metabolite is thought to be derived from the conjugation of benzoyl CoA with alanine. It is suggested that the excretion of benzoylalanine results from a reduction in the liver free glycine level caused by hippuric acid synthesis.
Authors:
T Shinka; Y Inoue; T Kuhara; M Matsumoto; I Matsumoto
Related Documents :
16484139 - Urinary desmosine as a biomarker in acute lung injury.
19112709 - Mammalian isovalthine metabolism.
2893719 - 19f nuclear magnetic resonance analysis of the carbamate reaction of alpha-fluoro-beta-...
21549829 - Oxidative stress in human lymphocytes treated with fatty acid mixture: role of caroteno...
4055069 - The validity of urinary metabolites as indicators of low exposures to toluene.
8308949 - Phenthoate metabolites in human poisoning.
17274449 - Synthesis and characterization of a ph-sensitive hydrogel made of pyruvic-acid-modified...
12083879 - Biosynthesis of strawberry aroma compounds through amino acid metabolism.
1360309 - Physical and mental fatigue: metabolic mechanisms and importance of plasma amino acids.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  151     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-18     Completed Date:  1985-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  293-300     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alanine / analogs & derivatives*,  urine
Ammonia / blood*
Benzoates / therapeutic use*
Benzoic Acid
Carboxylic Acids / urine
Child, Preschool
Chromatography, Gas
Female
Gas Chromatography-Mass Spectrometry
Humans
Infant
Infant, Newborn
Metabolism, Inborn Errors / drug therapy,  urine*
Chemical
Reg. No./Substance:
0/Benzoates; 0/Carboxylic Acids; 2198-64-3/N-benzoylalanine; 56-41-7/Alanine; 65-85-0/Benzoic Acid; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Age and sex dependency of the biochemical indices of bone remodelling.
Next Document:  Bile acid therapies applied to patients suffering from cerebrotendinous xanthomatosis.