Document Detail

Benzoylalanine: detection and identification of an alanine conjugate with benzoic acid in hyperammonemic patients treated with sodium benzoate.
MedLine Citation:
PMID:  4053389     Owner:  NLM     Status:  MEDLINE    
Urine of four hyperammonemic patients who were treated with large amounts of sodium benzoate were analyzed. Gas chromatographic and gas chromatograph-mass spectrometric analysis showed the presence of large amounts of benzoylalanine in addition to much hippuric acid. Benzoylalanine was identified by comparison with an authentic standard by means of its mass spectrum and the gas chromatographic retention time of its trimethylsilyl derivative. This abnormal metabolite is thought to be derived from the conjugation of benzoyl CoA with alanine. It is suggested that the excretion of benzoylalanine results from a reduction in the liver free glycine level caused by hippuric acid synthesis.
T Shinka; Y Inoue; T Kuhara; M Matsumoto; I Matsumoto
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  151     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-18     Completed Date:  1985-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  293-300     Citation Subset:  IM    
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MeSH Terms
Alanine / analogs & derivatives*,  urine
Ammonia / blood*
Benzoates / therapeutic use*
Benzoic Acid
Carboxylic Acids / urine
Child, Preschool
Chromatography, Gas
Gas Chromatography-Mass Spectrometry
Infant, Newborn
Metabolism, Inborn Errors / drug therapy,  urine*
Reg. No./Substance:
0/Benzoates; 0/Carboxylic Acids; 2198-64-3/N-benzoylalanine; 56-41-7/Alanine; 65-85-0/Benzoic Acid; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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