| Benzotriazole-Mediated Synthesis of Aza-peptides: En Route to an Aza-Leuenkephalin Analogue. | |
| | |
MedLine Citation:
|
PMID: 23373789 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Novel N-(N-Pg-azadipeptidoyl)benzotriazoles 20a-e couple efficiently with alpha-amino acids 21a-e, dipeptides 22a-c, aminoxyacetic acid 23a, depsidipeptide 23b and alpha-hydroxy-beta-phenylpropionic acid 27 yielding respectively, azatripeptides 24a-g, azatetrapeptides 25a-b, a hybrid azatripeptide with an oxyamide bond 26a, a hybrid azatetrapeptide with an ester bond 26b and a hybrid azatripeptide with an ester bond 28. A new protocol for the synthesis of N-Pg-azatripeptides 33a-b and 35a-b, each containing a natural amino acid at the N-terminus, avoids the low coupling rates of the aza-amino acid residue and enables the solution phase synthesis of an azaphenylalanine analogue of Leu-enkephalin 40. |
| | |
Authors:
|
Nader E Abo-Dya; Suvendu Biswas; Akash Basak; Ilker Avan; Khalid A Alamry; Alan R Katritzky |
Related Documents
:
|
15140949 - A universal evolutionary index for amino acid changes. 14348199 - The incorporation of glycerol and lysine into the lipid fraction of staphylococcus aureus. 15041779 - Effects of supplemental l-methionine on e-64 [trans-epoxysuccinyl-1-leucyl-amido (4-gua... 18323819 - Quantitative proteomics using stable isotope labeling with amino acids in cell culture. 685869 - Amino acid and protein metabolism in renal failure. 3733319 - Characteristic sequential residue environment of amino acids in proteins. 9747539 - Changes in arginine, pal activity, and nematode behavior in salinity-stressed citrus. 19919 - Purulent and non-purulent maxillary sinus secretions with respect to po2, pco2 and ph. 19999719 - Isolation and characterization of pokeweed mitogen-like phytomitogens from shoriku, phy... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-1 |
Journal Detail:
|
Title: The Journal of organic chemistry Volume: - ISSN: 1520-6904 ISO Abbreviation: J. Org. Chem. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Capillary force seeding of sphere-templated hydrogels for tissue engineered prostate cancer xenograf...
Next Document: Interobserver agreement of the old and the newly proposed ILAE epilepsy classification in children.