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Benzothiazoles: How Relevant in Cancer Drug Design Strategy?
MedLine Citation:
PMID:  23869774     Owner:  NLM     Status:  Publisher    
Heterocyclic compounds, analogues and derivatives have attracted great interest due to its diverse biological and pharmacological properties. Benzoheterocycles i.e., benzothiazoles, benzimidazoles and benzoxazoles are constituent of many bioactive heterocyclic compounds, and are of wider interest. These have been extensively studied for their biological activities, and serve as unique and versatile scaffolds for experimental drug design. In this chemical family, benzothiazole has considerable place in research especially in synthetic chemistry, pharmaceutical chemistry as well as in clinical applications because of its potent and significant pharmacological activities including very promising anti-tumor properties.This review first focuses on the chemical diversity of synthetic analogues of benzothiazole, and then on drug design strategy and mechanisms of action through its diverse biological targets, in which benzothiazole and its derivatives display their anticancer activity, and finally on the metabolism pattern of benzothiazole analogues.Analysis of the structure-activity relationships (SAR), quantitative structure-activity relationships (QSAR) as well as docking studies of this family of compounds highlight the existence of various potential leads for the development of novel anticancer agents and thus creating interest among the researchers to synthesize optimized variety of benzothiazole derivatives and to screen them for their anticancer activity.The endeavour of this review is to provide an overview of anti-cancer activities of benzothiazole analogues and discussion on structure activity relationship in context to different substitutions in the aromatic ring has also been presented.
Meenakshi Singh; Sushil K Singh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-16
Journal Detail:
Title:  Anti-cancer agents in medicinal chemistry     Volume:  -     ISSN:  1875-5992     ISO Abbreviation:  Anticancer Agents Med Chem     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265649     Medline TA:  Anticancer Agents Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University (BHU), Varanasi-221005, U.P., India.
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