Document Detail

Benzophenones and flavonoids from Hypericum maculatum and their antioxidant activities.
MedLine Citation:
PMID:  22077203     Owner:  NLM     Status:  Publisher    
The occurrence of three known benzophenones, namely annulatophenonoside, acetylannulatophenonoside and annulatophenone as well as a flavonol O-glycoside guajaverin in the aerial parts of Hypericum maculatum Crantz was established. In addition, hyperoside, isoquercitrin and miquelianin were isolated from this plant, as well. Radical scavenging and antioxidant activities of the isolated compounds were examined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) free radicals, ferric reducing antioxidant power (FRAP) assay and inhibition of lipid peroxidation in linoleic acid system by the ferric thiocyanate method. Isoquercitrin demonstrates the highest DPPH radical scavenging (96.6 ± 0.3%), FRAP (23.8 ± 0.2 Trolox equivalent, TE mol(-1)) and antioxidant activity in linoleic acid system. Guajaverin and acetylannulatophenonoside show significantly strong ABTS radical scavenging activity (93.9 ± 0.4% and 93.4 ± 0.6%, respectively), which is comparable to that of ascorbic acid (96.2 ± 0.4%).
Dimitrina Zheleva-Dimitrova; Paraskev Nedialkov; Ulrich Girreser; Gerassim Kitanov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-11
Journal Detail:
Title:  Natural product research     Volume:  -     ISSN:  1478-6427     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Department of Pharmacognosy, Faculty of Pharmacy , Medical University of Sofia , Dunav str. 2 , 1000 Sofia , Bulgaria.
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