| Benzofuranone derivatives as effective small molecules related to insulin amyloid fibrillation: a structure-function study. | |
| | |
MedLine Citation:
|
PMID: 21791011 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Amyloids are protein fibrils of nanometer size resulting from protein self-assembly. They have been shown to be associated with a wide variety of diseases such as Alzheimer's and Parkinson's, and may contribute to various other pathological conditions, known as amyloidoses. Insulin is prone to form amyloid fibrils under slightly destabilizing conditions in vitro and may form amyloid structures when subcutaneously injected in diabetic patients. There is a great deal of interest in developing novel small molecule inhibitors of amyloidogenic processes, as potential therapeutic compounds. In this study, the effects of five new synthetic benzofuranone derivatives were investigated on the insulin amyloid formation process. Protein fibrillation was analyzed by Thioflavine-T fluorescence, Congo red binding, circular cichroism and electron microscopy. Despite high structural similarity, one of the five tested compounds was observed to enhance amyloid fibrillation while the others inhibited the process when used at micro molar concentrations, which could make them interesting potential lead compounds for the design of therapeutic anti-amyloidogenic compounds. |
| | |
Authors:
|
Atefeh Rabiee; Azadeh Ebrahim-Habibi; Latifeh Navidpour; Dina Morshedi; Atiyeh Ghasemi; Marjan Sabbaghian; Maryam Nemati-Lay; Mohsen Nemat-Gorgani |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-25 |
Journal Detail:
|
Title: Chemical biology & drug design Volume: - ISSN: 1747-0285 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101262549 Medline TA: Chem Biol Drug Des Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 John Wiley & Sons A/S. |
Affiliation:
|
Department of Biology, College of Basic Sciences, Science and Research Branch, Islamic Azad University, Pounak, Tehran,Iran. Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran. Industrial and Environmental Biotechnology Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Department of Andrology, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran. Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis, Saccharide-Binding, and Anti-cancer Cell Proliferation Properties of Arylboronic Acid Der...
Next Document: Synthesis and anti-hypercholesterolemic evaluations of calcium salts of 4-substituted quinoline-base...