| Benzodiazepine prescription for patients in opioid maintenance treatment in Norway. | |
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MedLine Citation:
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PMID: 17478058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Opioid maintained patients report high levels of anxiety, but the use of benzodiazepines among these patients has been associated with negative outcomes such as increased risk of overdose and death and poorer retention in programmes. Previous research has used interview or urine analysis to assess benzodiazepine use. In this study a prescription database was applied. METHODS: The Norwegian Prescription Database covers all prescriptions for the entire population from 1 January 2004. Benzodiazepine prescriptions to patients receiving methadone (N=1364) or buprenorphine (N=805) in 2004 and 2005 were studied. Type and amount of drugs received were investigated. RESULTS: Overall 40% of the patients received at least one prescription for a benzodiazepine drug. Oxazepam was the most frequently prescribed drug. Female patients, methadone-maintained patients and patients in the liberal programmes received a prescription more often. Prescribed doses were high and highest in the liberal programmes. Older patients received more hypnotics. Dose of maintenance drug was positively related to amount of anxiolytics prescribed. CONCLUSIONS: This study showed that more benzodiazepines were prescribed to opioid maintenance treatment patients than previously shown by investigations using interview or urine analysis. The doses prescribed were generally high. In light of the negative outcomes following benzodiazepine use in these patients, Norwegian doctors need to review their prescription practices. |
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Authors:
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Jørgen G Bramness; Hege Kornør |
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Publication Detail:
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Type: Journal Article Date: 2007-05-02 |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 90 ISSN: 0376-8716 ISO Abbreviation: Drug Alcohol Depend Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-08-27 Completed Date: 2008-01-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: Ireland |
Other Details:
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Languages: eng Pagination: 203-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacoepidemiology, Division of Epidemiology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway. jorgen.bramness@fhi.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Benzodiazepines / therapeutic use* Buprenorphine / therapeutic use* Drug Prescriptions / statistics & numerical data* Drug Utilization Review* Female Humans Male Mental Health Services / organization & administration*, standards Methadone / therapeutic use* Middle Aged Narcotics / therapeutic use* Norway / epidemiology Opioid-Related Disorders / epidemiology*, rehabilitation* Physician's Practice Patterns* Substance Abuse Treatment Centers |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 12794-10-4/Benzodiazepines; 52485-79-7/Buprenorphine; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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