Document Detail

Benzodiazepine co-dependence exacerbates the opiate withdrawal syndrome.
MedLine Citation:
PMID:  15380286     Owner:  NLM     Status:  MEDLINE    
Patients seeking treatment for opiate withdrawal are commonly also dependent on benzodiazepines, although the interactions between benzodiazepine and opiate dependence and withdrawal syndromes have been subject to little systematic investigation. This is the first study comparing type, severity and course of opiate withdrawal symptoms between opiate dependent patients with, and without, concurrent benzodiazepine dependence. Patients dependent only on opiates (n = 39), and patients dependent on both opiates and benzodiazepines (n = 22), were recruited from consecutive admissions to an in-patient drug treatment unit. Quantity and duration of prior opiate use was similar for both groups. Patients completed daily self-ratings of opiate withdrawal (SOWS) for the duration of a standard in-patient detoxification treatment. Co-dependent patients were detoxified from benzodiazepines and opiates concurrently. Co-dependent patients reported a more severe withdrawal symptoms than patients withdrawing from opiates alone. Co-dependent patients had significantly more severe opiate withdrawal symptoms. Concurrent benzodiazepine withdrawal exacerbates opiate specific withdrawal symptoms. Possible psychological and neurophysiological mechanisms for the observed sensitisation are discussed.
Cornelis de Wet; Laurence Reed; Anthony Glasper; Paul Moran; Jennifer Bearn; Michael Gossop
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  76     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-21     Completed Date:  2005-01-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
Wickham Park House, South London & Maudsley NHS Trust Bethlem Royal Hospital, Monks Orchard Road, Beckenham, Kent BR3 3BX, UK.
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MeSH Terms
Benzodiazepines* / adverse effects
Chi-Square Distribution
Middle Aged
Opioid-Related Disorders / complications,  psychology,  therapy*
Substance Abuse Treatment Centers / methods,  statistics & numerical data
Substance Withdrawal Syndrome / complications,  psychology,  therapy*
Reg. No./Substance:

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