| Benzenepolycarboxylic acids with potential anti-hemorrhagic properties and structure-activity relationships. | |
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MedLine Citation:
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PMID: 22047800 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxylic acids and substituted benzoic acids against Protobothropsflavoviridis venom-induced hemorrhage. Pyromellitic acid (1,2,4,5-benzenetetracarboxylic acid) was found to be a potent inhibitor of hemorrhage, with an IC(50) value of 0.035μM. In addition, most of the antihemorrhagic activity of compounds tested in this experiment showed good correlation to acidity. |
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Authors:
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Hnin Thanda Aung; Toshiaki Nikai; Masatake Niwa; Yoshiaki Takaya |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: - ISSN: 1464-3391 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468-8503, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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