Document Detail

Benzene metabolites block gap junction intercellular communication. Role in hematotoxicity and leukemia?
MedLine Citation:
PMID:  15935824     Owner:  NLM     Status:  MEDLINE    
A metabolite of benzene, trans,trans-muconaldehyde (MUC) was found to be a strong inhibitor of gap junction intercellular communication (GJIC) with potency similar to that of chlordane. Hydroquinone and the MUC metabolite OH-M-CHO were also strong inhibitors of GJIC. The other MUC metabolites tested, CHO-M-COOH and OH-M-COOH had weak effects on GJIC, while COOH-M-COOH had no effect. Benzene showed no effect on GJIC. The relative potency of the metabolites on GJIC is similar to what is observed with regard to hematotoxic effects. The effect of MUC on GJIC took place in parallel with a strong cellular loss of connexin 43. Substances found to inhibit connexin 43 dependent GJIC have been shown to disrupt normal hematopoietic development. The finding that benzene metabolites interfere with gap junction functionality, and especially the loss of connexin 43 induced by MUC, should be considered concerning the mechanism of benzene-induced hematotoxicity.
Edgar Rivedal; Gisela Witz
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Publication Detail:
Type:  Journal Article     Date:  2005-04-11
Journal Detail:
Title:  Chemico-biological interactions     Volume:  153-154     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2005-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway.
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MeSH Terms
Aldehydes / metabolism,  toxicity*
Benzene / metabolism,  toxicity*
Cell Communication / drug effects*
Cell Line
Gap Junctions / drug effects*,  metabolism
Hematologic Diseases / metabolism
Hydroquinones / toxicity*
Leukemia / metabolism
Reg. No./Substance:
0/Aldehydes; 0/Hydroquinones; 123-31-9/hydroquinone; 3249-28-3/muconaldehyde; 71-43-2/Benzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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