| Benzene increases the ratio of arachidonic acids to docosahexaenoic acids and inhibits the de novo synthesis of ceramide in the rat liver. | |
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MedLine Citation:
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PMID: 15669040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study investigated the effects of inhalation exposure of benzene at 0, 10, 200 and 600 ppm for 1, 2 and 4 weeks on n-6 and n-3 fatty acids and ceramide levels in the rat liver. No significant difference in the ratio of saturated fatty acid to unsaturated fatty acid was found on increasing benzene exposure levels, but the ratio of saturated fatty acid to unsaturated fatty acid decreased with increasing benzene exposure times, with the exception of the phospholipids of rats exposed to 200 and 600 ppm of benzene. A significant increase in the ratio of arachidonic acid to docosahexaenoic acid was found in the phospholipids of rats exposed to 200 and 600 ppm of benzene for 4 weeks. In our study, no change in the relative amounts of sphingomyelin in phospholipids, due to benzene exposure at 600 ppm for 4 weeks resulted in the lack of sphingomyelin turnover. However, ceramide levels in the livers of rats exposed to 600 ppm of benzene for 4 weeks were significantly reduced upon increasing the benzene concentration. This result shows that the de novo synthesis of ceramide was significantly inhibited at higher levels of benzene and that the ratio of arachidonic acid to docosahexaenoic acid in phospholipids is dose-dependently related to benzene exposure. |
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Authors:
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Donggeun Sul; Ilsub Shim; Hosub Im; Namhee Won; Hae-Joon Kim; Eunil Lee |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied toxicology : JAT Volume: 25 ISSN: 0260-437X ISO Abbreviation: J Appl Toxicol Publication Date: 2005 Jan-Feb |
Date Detail:
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Created Date: 2005-01-31 Completed Date: 2005-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109495 Medline TA: J Appl Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 74-81 Citation Subset: IM |
Copyright Information:
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Copyright 2005 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Preventive Medicine, College of Medicine and Institute for Environmental Health, Medical Science Research Center, Korea University, Anam-dong 5 Ka, Sungbukku, Seoul 136-701, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acids / metabolism* Benzene / pharmacology* Ceramides / antagonists & inhibitors*, biosynthesis* Docosahexaenoic Acids / metabolism* Dose-Response Relationship, Drug Liver / chemistry, metabolism* Male Rats Rats, Sprague-Dawley Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Ceramides; 25167-62-8/Docosahexaenoic Acids; 71-43-2/Benzene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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