| Bennhold's analbuminemia: a follow-up study of the first two cases (1953-1992). | |
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MedLine Citation:
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PMID: 8621984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pair of siblings with analbuminemia were followed for 38 years. The female patient received replacement therapy with human serum albumin. Extreme lipodystrophy developed in this patient by the fourth decade of life. She had juvenile osteoporosis, which normalized under albumin replacement. She died from a granulosa cell cancer at age 69. Her brother never received albumin, even though his serum contained only 60 micrograms/ml of an albumin-like protein. He suffered from severe osteoporosis with gibbus formation, and he died from a colon carcinoma at age 59. Despite high cholesterol values and high levels of several blood clotting factors, neither of the patients had severe atherosclerosis or thrombotic events. Laboratory findings before and after infusion of large amounts of albumin into the sister point to a mechanism whereby albumin-bound substances can be passively transported from the bloodstream into the extravascular space and vice versa. |
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Authors:
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E Kallee |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 127 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-06-18 Completed Date: 1996-06-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 470-80 Citation Subset: AIM; IM |
Affiliation:
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Department IV, Medizinische Klinik, Eberhard-Karls Universitèt Tübingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Colonic Neoplasms / complications Female Follow-Up Studies Granulosa Cell Tumor / complications Humans Lipodystrophy / etiology Male Osteoporosis / drug therapy, etiology Ovarian Neoplasms / complications Serum Albumin / deficiency*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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