Document Detail

Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability.
MedLine Citation:
PMID:  9504469     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We determined the clinical utility of proton MR spectroscopy in defining the extent of disability in benign versus secondary-progressive multiple sclerosis (MS). METHODS: Thirty patients with clinically definite MS, including 16 patients with benign MS and 14 with secondary-progressive MS, and a group of 13 healthy volunteers were studied with combined stimulated-echo acquisition mode proton MR spectroscopy and MR imaging (all patients received contrast material). RESULTS: Acute enhancing lesions of benign and secondary-progressive MS were characterized by a reduction in N-acetylaspartate (NAA)/choline and NAA/creatine and an increase in inositol compounds/creatine as compared with normal white matter. Such variations were also detected in chronic unenhancing lesions in patients with secondary-progressive MS, although they were not found in chronic unenhancing lesions in patients with benign MS. Chronic lesions of the two forms of the disease have significative differences in NAA and inositol signals. CONCLUSION: Proton MR spectroscopy is able to show metabolic changes occurring in the white matter of patients with MS. Such changes differ according to the phase (acute versus chronic) and the clinical form (benign versus secondary-progressive) of the disease.
A Falini; G Calabrese; M Filippi; D Origgi; S Lipari; B Colombo; G Comi; G Scotti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  19     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-06     Completed Date:  1998-05-06     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-9     Citation Subset:  IM    
Department of Neuroradiology, Scientific Institute San Raffaele Hospital, University of Milan, Italy.
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MeSH Terms
Aspartic Acid / analogs & derivatives,  metabolism
Brain / pathology
Choline / metabolism
Creatine / metabolism
Disease Progression
Follow-Up Studies
Inositol / metabolism
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Middle Aged
Multiple Sclerosis / classification,  diagnosis*
Neurologic Examination*
Reg. No./Substance:
56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate

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