| Benign prostatic hyperplasia: the hypogonadal-obesity-prostate connection. | |
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MedLine Citation:
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PMID: 19394149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostatic enlargement occurs over the course of a lifetime and is associated with many risk factors. Recent observations demonstrate that valvular damage, occurring in the internal spermatic veins results in increased hydrostatic pressures that lead to venous backflow. Two consequences of venous backflow are the prolonged exposure to hydrostatic pressure and high testosterone levels that effect the prostate directly. Furthermore, aging and obesity related states have long been associated with BPH and diminished testosterone concentrations, which by itself, predisposes and allows for the preferential deposition of abdominal/visceral fat. The increasing abdominal obesity leads to elevated intra-abdominal pressure, which over time, causes increased venous pressure. Chronically elevated intra-abdominal venous pressure eventually causes progressive failure of the one way valves in the internal spermatic veins and venous insufficiency that leads to prostate damage. All of these factors promote conditions that cause chronic progressive prostatic disease and eventually BPH. |
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Authors:
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Paul G Cohen |
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Publication Detail:
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Type: Journal Article Date: 2009-04-24 |
Journal Detail:
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Title: Medical hypotheses Volume: 73 ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-05-27 Completed Date: 2009-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: United States |
Other Details:
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Languages: eng Pagination: 142-3 Citation Subset: IM |
Affiliation:
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Mercer University, Southern School of Pharmacy, Department of Pharmaceutical Sciences, P.O. Box 191405, Atlanta, Georgia 31119, USA. cohenpg@bellsouth.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Hypogonadism / pathology* Male Obesity / pathology* Prostate / pathology* Prostatic Hyperplasia / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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