Document Detail


Benign prostate hyperplasia: a review of the year's progress from bench to clinic.
MedLine Citation:
PMID:  21171199     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Therapeutic tools for classic benign prostate hyperplasia (BPH) have focused on the dynamic component of obstruction and/or elimination of the static component via surgical or pharmaceutical therapies. Unfortunately, an exact cause for this disease process has not been identified, but additional insight has been achieved. This article presents an update of the BPH literature with a special focus on basic science or translational studies concerned with the cause of clinically significant BPH with lower urinary tract symptoms (LUTS).
RECENT FINDINGS: Investigators are exploring connections between BPH with clinically significant LUTS, the metabolic syndrome, inflammation, alterations in cell signaling, and genetics which in turn has provided additional information concerning the pathogenesis, medical therapies as well as surgical therapies.
SUMMARY: BPH is a chronic, progressive disease with important care implications and financial risks to the healthcare system. Continued improvements in length of life will demand that we unlock the cause of LUTS secondary to BPH with the goal of prevention as the ideal therapy. Studies reported in the last year contributed to our understanding of the disease process and provide insight for additional studies.
Authors:
Robert F Donnell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current opinion in urology     Volume:  21     ISSN:  1473-6586     ISO Abbreviation:  Curr Opin Urol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200621     Medline TA:  Curr Opin Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  IM    
Affiliation:
Department of Urology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. rdonnell@mcw.edu
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