Document Detail

Benign partial epilepsy in infancy: myth or reality?
MedLine Citation:
PMID:  16822251     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Benign partial epilepsy in infancy (BPEI) was first described by Watanabe in 1987. The aim of this study is to describe a series of infants from the United States to characterize this entity further. METHODS: Among patients with the diagnosis of epilepsy followed up at our institution between 2002 and 2004, those satisfying the criteria for BPEI were included in a retrospective study. RESULTS: Sixteen (10.2%) of 150 patients with new onset of epilepsy younger than 2 years were identified. The mean age at seizure onset was 8 months. Four (25%) infants had a family history of benign seizures. All infants were neurologically and developmentally normal at the onset of seizures. The seizures occurred in clusters in 75% of patients, predominantly in wakefulness. The initial manifestation was behavioral arrest with staring (69%) and apnea with cyanosis or pallor (37.5%). These symptoms were followed by deviation of eyes or head or both (56%), mild clonic movements (31%), or increased limb tone (35%). Secondary generalization was noticed in 37.5% of patients. All infants had normal interictal EEGs and brain MRIs. Ictal EEGs disclosed electrographic seizures in 50% of patients (temporal origin in 62% and central in 38%). Fifteen (94%) patients were treated with AEDs with good response. The mean duration of treatment was 12.4 months. The final developmental assessment of all patients was normal. CONCLUSIONS: We believe that BPEI exists as a unique entity and should be included in the differential diagnosis of epilepsies in infancy with partial origin.
Joseph Kaleyias; Divya S Khurana; Ignacio Valencia; Agustin Legido; Sanjeev V Kothare
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  47     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-06     Completed Date:  2006-07-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1043-9     Citation Subset:  IM    
Department of Pediatrics, Division of Neurology, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134-1095, USA.
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MeSH Terms
Age Factors
Age of Onset
Anticonvulsants / therapeutic use
Behavioral Symptoms / diagnosis,  epidemiology
Brain / pathology
Diagnosis, Differential
Electroencephalography / statistics & numerical data
Epilepsies, Partial / diagnosis*,  drug therapy,  epidemiology*
Follow-Up Studies
Infant, Newborn
Magnetic Resonance Imaging / statistics & numerical data
Retrospective Studies
Terminology as Topic
Treatment Outcome
United States / epidemiology
Reg. No./Substance:

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