Document Detail

Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses.
MedLine Citation:
PMID:  18382364     Owner:  NLM     Status:  MEDLINE    
Benign metastasizing leiomyomas are rare tumors, which are typically found in the lungs and, thus, might be confused with leiomyosarcomas. Further, it is not clear whether the term "benign metastasizing leiomyoma" is a misnomer and whether these lesions actually represent low-grade malignant tumors that have a low proliferation index. Micro-RNAs (miRNAs) are small noncoding RNAs, which repress translation. The altered expression of miRNAs has been strongly correlated with the malignant phenotype. In this study, the histologic features, Ki67 index, p53, bcl-2, and miRNA expression were studied in 15 leiomyosarcomas (11 primary lesions and 4 metastases), 8 leiomyomas, and 10 cases of benign metastasizing leiomyoma (9 pulmonary lesions and 1 primary uterine lesion). As expected, the Ki67 index for the benign metastasizing leiomyomas was equivalent to that for the leiomyomas and statistically less than that for the leiomyosarcomas. The mean index was 2.3% (range: 0.9% to 8.8%) for the leiomyomas and 3.4% (range: 0.7% to 8.1%) for the benign metastasizing leiomyomas compared with 28.6% (range: 14.4% to 62.0%) for the leiomyosarcomas (P<0.025). The miRNA, miR-221, which has been associated with a variety of cancers, was detected by in situ hybridization in 13/15 leiomyosarcomas, 0/8 leiomyomas, and 0/10 benign metastasizing leiomyomas. In conclusion, benign metastasizing leiomyomas are indeed most likely benign lesions, and up-regulation of miR-221 expression is an accurate way to differentiate leiomyosarcoma from benign metastasizing leiomyoma.
Gerard J Nuovo; Thomas D Schmittgen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diagnostic molecular pathology : the American journal of surgical pathology, part B     Volume:  17     ISSN:  1533-4066     ISO Abbreviation:  Diagn. Mol. Pathol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2008-10-21     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9204924     Medline TA:  Diagn Mol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
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MeSH Terms
Diagnosis, Differential
In Situ Hybridization
Ki-67 Antigen / biosynthesis
Leiomyoma / genetics*,  metabolism,  pathology
Leiomyosarcoma / genetics,  metabolism,  pathology
Lung Neoplasms / genetics*,  metabolism,  secondary
MicroRNAs / genetics*
Middle Aged
Proto-Oncogene Proteins c-bcl-2 / biosynthesis
Tumor Markers, Biological / genetics*
Tumor Suppressor Protein p53 / biosynthesis
Uterine Neoplasms / genetics*,  metabolism,  pathology
Grant Support
CA114304/CA/NCI NIH HHS; R33 CA114304/CA/NCI NIH HHS; R33 CA114304-03/CA/NCI NIH HHS
Reg. No./Substance:
0/Ki-67 Antigen; 0/MIRN221 microRNA, human; 0/MicroRNAs; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53

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