Document Detail


Benign mesenchymal tumours and tumour-like lesions in end-stage renal disease.
MedLine Citation:
PMID:  23020314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS:   Mesenchymal neoplasms of the kidney are rare, and most represent sporadic angiomyolipomas. A few haemangiomas have been reported in end-stage renal disease (ESRD) but, to date, no study has focused on the frequency and morphological spectrum of mesenchymal lesions in ESRD.
METHODS AND RESULTS:   We evaluated retrospectively 90 nephrectomy specimens with ESRD. Haemangiomas were detected in eight cases (8.8%; six males and two females; mean age: 55 years); four were multifocal and four had concurrent renal epithelial neoplasms. Lesions involved the medulla (three), cortex (two) or both (three), and the size range was 1-25 mm (mean 4.8 mm). Histologically, all were capillary haemangiomas with an at least focally detectable spleen-like anastomosing pattern. All tumours stained positively for CD31 and FLI-1, but none expressed pankeratin (KL-1), podoplanin/D2-40, HHV8 or GLUT-1. Minute angiomyolipomas (mean size 2.3 mm) were detected in four patients (mean age 49.5 years). Tumour-like smooth muscle proliferations were seen surrounding muscular arteries (eight), occasionally admixed with fat extending from the renal sinus mimicking angiomyolipoma. No similar tumours were found in 105 control kidneys.
CONCLUSIONS:   Benign haemangiomas are not uncommon in ESRD, but may be under-recognized. They display distinctive morphology and should be distinguished from angiosarcomas and capillary-rich renal cell carcinomas.
Authors:
Maike Büttner; Verena Kufer; Kathrin Brunner; Arndt Hartmann; Kerstin Amann; Abbas Agaimy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-28
Journal Detail:
Title:  Histopathology     Volume:  62     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-06-13     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Limited.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / complications,  metabolism,  pathology*
Adult
Aged
Aged, 80 and over
Angiomyolipoma / complications,  metabolism,  pathology*
Antigens, CD31 / metabolism
Capillaries / pathology
Carcinoma, Renal Cell / blood supply,  diagnosis
Diagnosis, Differential
Female
Hemangioma / complications,  metabolism,  pathology*
Hemangiosarcoma / diagnosis
Humans
Kidney Failure, Chronic / complications,  metabolism,  pathology*
Kidney Neoplasms / complications,  metabolism,  pathology*
Male
Microfilament Proteins / metabolism
Middle Aged
Neoplasms, Multiple Primary
Nephrectomy
Receptors, Cytoplasmic and Nuclear / metabolism
Retrospective Studies
Tumor Markers, Biological / metabolism
Young Adult
Chemical
Reg. No./Substance:
0/Antigens, CD31; 0/FLII protein, human; 0/Microfilament Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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