Document Detail


Benign intracranial hypertension in chronic myeloid leukemia.
MedLine Citation:
PMID:  8260157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a patient with chronic myeloid leukemia (CML) who had marked bilateral disc swelling as part of his initial presentation. This occurred in the setting of raised intracranial pressure (ICP), with normal cerebrospinal fluid (CSF) composition and cell content, and normal neuroimaging. We discuss the possible mechanisms which could lead to disc swelling in CML and conclude that the raised ICP and subsequent papilloedema in our patient were the result of poor absorption of CSF into the dural venous sinuses. We propose that the very high white cell count (WCC) led to a hyperviscosity state which resulted in poor absorption of CSF and in so doing, created a clinical picture of benign intracranial hypertension (BIH).
Authors:
R H Guymer; J D Cairns; J O'Day
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Australian and New Zealand journal of ophthalmology     Volume:  21     ISSN:  0814-9763     ISO Abbreviation:  Aust N Z J Ophthalmol     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1994-01-27     Completed Date:  1994-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8505423     Medline TA:  Aust N Z J Ophthalmol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
Affiliation:
St Vincent's Hospital, Fitzroy, Victoria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Cell Count
Blood Pressure
Bone Marrow / pathology
Fluorescein Angiography
Fundus Oculi
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications*,  pathology
Leukocyte Count
Male
Papilledema / complications
Pseudotumor Cerebri / etiology*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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