| Benign intracranial hypertension: correlation of cerebral blood flow with disease severity. | |
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MedLine Citation:
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PMID: 11311474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Benign intracranial hypertension (BIH) is characterized by symptoms and signs of raised intracranial pressure in the absence of an intracranial mass lesion, infection or hydrocephalus. The purpose of this study was to evaluate the effect of disease severity on cerebral blood flow in patients with BIH on acetazolamide therapy. METHODS: 11 patients (nine females, two males; mean age 30.5 years; range 22-29 years) with BIH were studied. All patients underwent CT and MRI scanning which were normal. The CSF pressure of all patients was above 200 mm H2O. All patients were under treatment with acetazolamide (1 g/day). Disease severity was determined by visual field examination and by clinical symptoms. Five patients were categorized into mild to moderate BIH (group I) and six patients had severe BIH (group II). All patients underwent perfusion brain SPECT with 740 MBq of Tc-99m-HMPAO. RESULTS: Brain perfusion abnormalities were observed in six of the 11 patients. One out of five patients in group I (20%) and five out of six patients (83%) in group II, had abnormal SPECT findings (P<0.04). In four patients of group II the left parietal lobe was involved and another patient had a right occipital abnormality. The single patient from group I with SPECT abnormalities demonstrated focal decreased perfusion in the left temporal area and decreased perfusion in the left caudate nucleus. CONCLUSION: Patients with severe degree of BIH have a higher incidence of cerebral perfusion abnormalities. This group may have an increased risk of cerebrovascular complications. The continuous administration of acetazolamide which affects the vascular autoreactivity may contribute to the regional hypoperfusion. Further studies are recommended to evaluate the natural course of disease versus iatrogenic treatment effects. |
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Authors:
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M Lorberboym; Y Lampl; A Kesler; M Sadeh; N Gadot |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 103 ISSN: 0303-8467 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-20 Completed Date: 2001-09-06 Revised Date: 2009-10-14 |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 33-6 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, The Edith Wolfson Medical Center, 58100, Holon, Israel. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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adverse effects,
therapeutic use* Adult Brain / blood supply* Cerebrovascular Circulation Chronic Disease Diuretics / adverse effects, therapeutic use* Female Humans Male Pseudotumor Cerebri / drug therapy*, physiopathology, radionuclide imaging Radiopharmaceuticals / therapeutic use Severity of Illness Index Technetium Tc 99m Exametazime / diagnostic use Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime; 59-66-5/Acetazolamide |
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