| Benign brain stem lesions in pediatric patients with neurofibromatosis: case reports. | |
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MedLine Citation:
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PMID: 2513523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The symptoms and clinical courses of 4 patients with neurofibromatosis and lesions of the brain stem identifiable on computed tomographic and/or magnetic resonance imaging scans are described. Two patients underwent biopsy and both had low-grade astrocytomas with no evidence of anaplasia. Both received radiation and chemotherapy. The other 2 patients have been monitored without biopsy or treatment. Three patients are alive and clinically stable, having been followed up for an average of 4 years; neuroimaging studies have shown no change in their tumors. The fourth patient died of a supratentorial primitive neuroectodermal tumor. Imaging studies had shown no change in his brain stem lesion, which at autopsy was found to be a focal collection of fibrillary astrocytes. These data suggest that some patients with brain stem lesions and neurofibromatosis may have a prognosis distinctly different from that of the typical patient with a brain stem glioma. We recommend caution against aggressive operative and adjuvant therapy for brain stem lesions in patients with neurofibromatosis, unless progression of the lesion is documented clinically and/or by imaging. |
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Authors:
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C Raffel; J G McComb; S Bodner; F E Gilles |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurosurgery Volume: 25 ISSN: 0148-396X ISO Abbreviation: Neurosurgery Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-01-31 Completed Date: 1990-01-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 959-64 Citation Subset: IM |
Affiliation:
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Divisions of Neurosurgery, Children's Hospital of Los Angeles, California. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Astrocytoma / complications*, diagnosis, radiography Brain Neoplasms / complications*, diagnosis, radiography Brain Stem / pathology* Child Child, Preschool Female Humans Magnetic Resonance Imaging Neurofibromatosis 1 / complications* Tomography, X-Ray Computed |
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