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Benign Hepatic Nodular Lesions After Treatment For Childhood Cancer.
MedLine Citation:
PMID:  22922376     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Benign nodular hepatic regenerating lesions such as focal nodular hyperplasia (FNH) have been reported as rare complications of the anti-neoplastic therapy received during infancy. Little is known about the risk factors associated to the onset of these lesions and their diagnostic management. METHODS:: We have analysed a series of benign hepatic nodular lesions occurring in children previously treated for malignant tumours c/o Institution in a period of 11 years. An extensive description of the imaging presentation of the lesions has been provided to facilitate the differential diagnosis and a risk factors analysis has been conducted. RESULTS:: Fourteen diagnoses (10 FNH and 4 hemangiomas) of benign nodular hepatic lesions have been found. Hematopoietic stem cell transplantation (HSCT) is the most important statistically independent risk factor associated to the development of these lesions, especially for FNH. No malignant transformation of nodules has been recorded during a median follow-up time of 4 years. CONCLUSIONS:: In our experience, FNH is the most frequent benign nodular hepatic lesions occurring after treatment for childhood cancer. HSCT is the most important risk factor to be taken in account. After a secure diagnosis of these benign lesions, only a close imaging follow-up is recommended.
R Masetti; A Colecchia; R Rondelli; A Martoni; F Vendemini; C Biagi; A Prete; D Festi; M Lima; A Pession
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Paediatric Oncology and Haematology Unit "Lalla Seràgnoli, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna Italy †Department of Clinical Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy ‡Department of Paediatric Surgery, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
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