Document Detail

Benfluorex: increasing reports of valve disorders.
MedLine Citation:
PMID:  20455335     Owner:  NLM     Status:  MEDLINE    
Benfluorex is an amphetamine appetite suppressant derived from fenfluramine. In France, about 30 cases of pulmonary arterial hypertension and a similar number of valve disorders, often involving several valves, were reported between 1998 and 2009. Benfluorex has the same adverse effects as those that led to the withdrawal of amphetamine appetite suppressants such as fenfluramine.There is no proven benefit that justifies exposing patients to these risks. The French National Pharmacovigilance Committee simply proposed "to await the results of planned and ongoing studies". However, it would be in patients' best interests to withdraw this drug from the market.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  19     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  France    
Other Details:
Languages:  eng     Pagination:  17     Citation Subset:  T    
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MeSH Terms
Appetite Depressants / adverse effects*,  therapeutic use
Fenfluramine / adverse effects,  analogs & derivatives*,  therapeutic use
France / epidemiology
Heart Valve Diseases / chemically induced*,  epidemiology
Hypertension, Pulmonary / chemically induced
Product Recalls and Withdrawals
Reg. No./Substance:
0/Appetite Depressants; 23602-78-0/benfluorex; 458-24-2/Fenfluramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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