| Benfluorex: increasing reports of valve disorders. | |
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MedLine Citation:
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PMID: 20455335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Benfluorex is an amphetamine appetite suppressant derived from fenfluramine. In France, about 30 cases of pulmonary arterial hypertension and a similar number of valve disorders, often involving several valves, were reported between 1998 and 2009. Benfluorex has the same adverse effects as those that led to the withdrawal of amphetamine appetite suppressants such as fenfluramine.There is no proven benefit that justifies exposing patients to these risks. The French National Pharmacovigilance Committee simply proposed "to await the results of planned and ongoing studies". However, it would be in patients' best interests to withdraw this drug from the market. |
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Authors:
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prescrire international Volume: 19 ISSN: 1167-7422 ISO Abbreviation: Prescrire Int Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2010-05-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9439295 Medline TA: Prescrire Int Country: France |
Other Details:
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Languages: eng Pagination: 17 Citation Subset: T |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Appetite Depressants
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adverse effects*,
therapeutic use Fenfluramine / adverse effects, analogs & derivatives*, therapeutic use France / epidemiology Heart Valve Diseases / chemically induced*, epidemiology Humans Hypertension, Pulmonary / chemically induced Product Recalls and Withdrawals |
| Chemical | |
Reg. No./Substance:
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0/Appetite Depressants; 23602-78-0/benfluorex; 458-24-2/Fenfluramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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