Document Detail


Benefits of short-term dietary restriction in mammals.
MedLine Citation:
PMID:  23376627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary or calorie restriction (DR, CR), defined as reduced food intake without malnutrition, imparts many benefits in model organisms. Extended longevity is the most popularized benefit but the least clinically relevant due to the requirement for long-term food restriction. DR also promotes stress resistance and metabolic fitness. Emerging data in experimental models and in humans indicate that these benefits occur rapidly upon initiation of DR, suggesting potential clinical relevance. Here we review data on the ability of short-term DR to induce beneficial effects on clinically relevant endpoints including surgical stress, inflammation, chemotherapy and insulin resistance. The encouraging results obtained in these preclinical and clinical studies, and the general lack of mechanistic understanding, both strongly suggest the need for further research in this emerging area.
Authors:
Lauren T Robertson; James R Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-02-01
Journal Detail:
Title:  Experimental gerontology     Volume:  48     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-02     Completed Date:  2014-03-11     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1043-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animal Husbandry
Animals
Antineoplastic Agents / adverse effects
Caloric Restriction*
Disease Models, Animal
Energy Metabolism / physiology
Fasting / physiology
Humans
Immunity, Innate / physiology
Inflammation / immunology
Ischemic Postconditioning / methods
Ischemic Preconditioning / methods
Longevity / physiology
Mammals
Neoplasms / diet therapy
Poultry
Reperfusion Injury / diet therapy,  immunology
Shock, Septic / immunology
Signal Transduction / physiology
Up-Regulation
Weight Loss / physiology
Grant Support
ID/Acronym/Agency:
AG036712/AG/NIA NIH HHS; DK090629/DK/NIDDK NIH HHS; R01 AG036712/AG/NIA NIH HHS; R01 DK090629/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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