Document Detail


Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjects.
MedLine Citation:
PMID:  17069820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS: Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to maintain dietary and physical activity patterns during the period of study. Blood pressure, anthropometric, body composition and dietary information with fasting blood samples to determine traditional and novel CHD risk markers and plasma fatty acids were obtained before and after each period. RESULTS: Compared to no-fish, eating salmon significantly decreased systolic, diastolic and mean arterial blood pressure by 4%, triglycerides by 15%, and LDL-cholesterol by 7%, and significantly increased HDL-cholesterol by 5% (P<0.05). The changes in blood pressure and lipids alone with salmon intake predict around a 25% reduction in CHD risk based on the PROCAM risk calculator. Plasma adiponectin demonstrated a trend towards improvement (8.39 micromol/L with salmon and 7.52 with no-fish; P=0.086) but no significant changes were found either in plasma leptin, glucose or insulin after salmon consumption. CONCLUSIONS: Daily consumption of salmon improves traditional risk predictors of CHD in non-obese subjects. Adiponectin may be involved but the impact on novel risk factors needs study in high-risk subjects.
Authors:
Jose J Lara; Maria Economou; A Michael Wallace; Anne Rumley; Gordon Lowe; Christine Slater; Muriel Caslake; Naveed Sattar; Michael E J Lean
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-27
Journal Detail:
Title:  Atherosclerosis     Volume:  193     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  213-21     Citation Subset:  IM    
Affiliation:
Department of Human Nutrition, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Blood Pressure
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Disease / blood,  etiology,  physiopathology,  prevention & control*
Diet*
Dietary Fats, Unsaturated / administration & dosage
Female
Fish Oils / administration & dosage
Humans
Lipids / blood
Male
Middle Aged
Risk Factors
Salmon*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats, Unsaturated; 0/Fish Oils; 0/Lipids; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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