| Benefits and risks of iron supplementation in anemic neonatal pigs. | |
| | |
MedLine Citation:
|
PMID: 20805566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Iron deficiency is a common health problem. The most severe consequence of this disorder is iron deficiency anemia (IDA), which is considered the most common nutritional deficiency worldwide. Newborn piglets are an ideal model to explore the multifaceted etiology of IDA in mammals, as IDA is the most prevalent deficiency disorder throughout the early postnatal period in this species and frequently develops into a critical illness. Here, we report the very low expression of duodenal iron transporters in pigs during the first days of life. We postulate that this low expression level is why the iron demands of the piglet body are not met by iron absorption during this period. Interestingly, we found that a low level of duodenal divalent metal transporter 1 and ferroportin, two iron transporters located on the apical and basolateral membrane of duodenal absorptive enterocytes, respectively, correlates with abnormally high expression of hepcidin, despite the poor hepatic and overall iron status of these animals. Parenteral iron supplementation by a unique intramuscular administration of large amounts of iron dextran is current practice for the treatment of IDA in piglets. However, the potential toxicity of such supplemental iron implies the necessity for caution when applying this treatment. Here we demonstrate that a modified strategy for iron supplementation of newborn piglets with iron dextran improves the piglets' hematological status, attenuates the induction of hepcidin expression, and minimizes the toxicity of the administered iron. |
| | |
Authors:
|
Paweł Lipinski; Rafał R Starzyński; François Canonne-Hergaux; Barbara Tudek; Ryszard Oliński; Paweł Kowalczyk; Tomasz Dziaman; Olivier Thibaudeau; Mikołaj A Gralak; Ewa Smuda; Jarosław Woliński; Agnieszka Usińska; Romuald Zabielski |
Related Documents
:
|
2357866 - Differences in stereoselective disposition of propranolol do not explain sensitivity di... 16758136 - Dietary determinants of post-menopausal bone loss at the lumbar spine: a possible benef... 17417756 - In vitro comparison of two bioartificial liver support systems: mels cellmodule and amc... 4078356 - Effect of clofazimine and dapsone on rifampicin (lositril) pharmacokinetics in multibac... 7390056 - Acute hemorrhagic pancreatic necrosis in mice. alterations of pancreatic lipase activit... 1332746 - Gastrointestinal implications in the rat of wheat bran, oat bran and pea fibre. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of pathology Volume: 177 ISSN: 1525-2191 ISO Abbreviation: Am. J. Pathol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-31 Completed Date: 2010-12-13 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 1233-43 Citation Subset: AIM; IM |
Affiliation:
|
Department of Molecular Biology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland. P.Lipinski@ighz.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Anemia, Iron-Deficiency / blood, drug therapy*, metabolism Animals Animals, Newborn Blotting, Western Cation Transport Proteins / genetics, metabolism Duodenum / metabolism* Erythrocyte Count Immunohistochemistry Intestinal Mucosa / metabolism* Iron, Dietary / metabolism, therapeutic use* Reverse Transcriptase Polymerase Chain Reaction Statistics, Nonparametric Swine |
| Chemical | |
Reg. No./Substance:
|
0/Cation Transport Proteins; 0/Iron, Dietary; 0/metal transporting protein 1; 0/solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sliding set-points of immune responses for therapy of autoimmunity.
Next Document: Altered ferritin subunit composition: change in iron metabolism in lens epithelial cells and downstr...