Document Detail

Benefits of radioimmunoguided surgery for pelvic recurrence.
MedLine Citation:
PMID:  11373109     Owner:  NLM     Status:  MEDLINE    
AIM: Surgery for recurrent rectal cancer is usually traumatic and of questionable curative value. The use of radioimmunoguided surgery (RIGS) in enhancing the surgeon's assessment of the extent of disease in these patients was investigated. METHODS: Twenty-one patients diagnosed with recurrent pelvic cancer were operated using the RIGS(O)system. Preoperative assessment included CTs of chest, abdomen and pelvis as well as colonoscopy. Patients were injected with CC49, a monoclonal antibody (MoAb) labelled with 125I. Surgical exploration was followed by survey with the gamma-detecting probe. RESULTS: Surgical exploration identified eight intra-colorectal recurrences, nine extra-colonic pelvic recurrences and five extra-pelvic lymph node metastases. RIGS exploration confirmed all intra-colonic recurrences except for one (patient with no MoAb localization), identified 13 pelvic recurrences and 10 lymph node metastases. There were seven patients with occult findings (33%), resulting in a modified surgical procedure. Surgery included five abdomino-perineal resections, six low anterior resections, seven excisions of presacral tumour, eight total abdominal hysterectomy and bilateral salpingo-oophorectomy, one pelvic exenteration and one post-exenteration. There were no operative deaths. Eight patients had minor complications, and one patient had a major complication with reoperation due to urinary leak. The mean follow-up was 18 months. Ten patients died of disease. CONCLUSION: Although not curative, RIGS can help the surgeon in the decision-making process through better disease staging.
R Haddad; S Avital; A Troitsa; J Chen; M Baratz; E Brazovsky; G Gitstein; H Kashtan; Y Skornick; S Schneebaum
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology     Volume:  27     ISSN:  0748-7983     ISO Abbreviation:  Eur J Surg Oncol     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-24     Completed Date:  2001-06-21     Revised Date:  2009-07-24    
Medline Journal Info:
Nlm Unique ID:  8504356     Medline TA:  Eur J Surg Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-301     Citation Subset:  IM    
Copyright Information:
Copyright Harcourt Publishers Limited.
Department of Surgery 'A', Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
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MeSH Terms
Aged, 80 and over
Antibodies, Monoclonal / diagnostic use
Colectomy / methods*
Iodine Radioisotopes / diagnostic use
Length of Stay
Liver Neoplasms / secondary
Lymphatic Metastasis
Middle Aged
Neoplasm Recurrence, Local / mortality,  radionuclide imaging*,  surgery*
Neoplasm Staging
Pelvic Neoplasms / mortality,  radionuclide imaging,  secondary*,  surgery*
Preoperative Care
Radioimmunodetection / methods*
Rectal Neoplasms / mortality,  radionuclide imaging*,  surgery*
Survival Rate
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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