Document Detail

Benefits of placental biopsies for rapid karyotyping in the second and third trimesters (late chorionic villus sampling) in high-risk pregnancies.
MedLine Citation:
PMID:  2187349     Owner:  NLM     Status:  MEDLINE    
In a total of 301 placental biopsies in the second and third trimesters, 225 were performed because of suspicious ultrasonographic findings. In this group there was a high rate of aneuploidies (20%). As opposed to the alternative methods for rapid karyotyping, placental biopsies can easily be performed even in pregnancies with abnormal amounts of amniotic fluid. Oligohydramnios and polyhydramnios were key ultrasonographic findings in 38% of cases and were found to be associated with 22% of abnormal chromosomal findings. Suggestive ultrasonographic findings seem to justify the exclusive use of direct preparation.
W Holzgreve; P Miny; B Gerlach; A Westendorp; D Ahlert; J Horst
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  162     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-15     Completed Date:  1990-06-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1188-92     Citation Subset:  AIM; IM    
Zentrum für Frauenheilkunde, Münster, FRG.
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MeSH Terms
Amniotic Fluid
Chorionic Villi Sampling* / methods
Chromosome Aberrations / diagnosis*,  genetics
Chromosome Disorders
Fetal Diseases / diagnosis*,  genetics
Polyhydramnios / diagnosis
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prenatal Diagnosis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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