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Benefits of neuromuscular electrical stimulation prior to endurance training in patients with cystic fibrosis and severe pulmonary dysfunction.
MedLine Citation:
PMID:  22911373     Owner:  NLM     Status:  Publisher    
ABSTRACT BACKGROUND: We investigated the effect of neuromuscular electrical stimulation (NMES) training prior to endurance training in patients with cystic fibrosis (CF) and severe pulmonary obstruction. METHODS: Fourteen patients with CF (FEV1 = 35 ± 11% pred.) were prospectively randomized to either a 6 week NMES training program (n=7) or a 6 week control period (n=7) both followed by ergocycle training (8 weeks) (NMES+ERGO and Control+ERGO groups). Measurements were pulmonary function, mid-thigh circumference, quadriceps strength, 6-minute walking distance (6MWD), maximal exercise capacity on a cycloergometer, plasma biomarkers, insulin resistance (HOMA indexes) and quality of life (CFQ14+, BDI-TDI). RESULTS: NMES+ERGO greatly improved mid-thigh circumference (+2.6 ± 0.9 vs. -0.4 ± 1.4 cm), quadriceps strength (+6 ± 5 vs. -2 ± 2 kg) and BMI (+0.6 ± 0.6 vs. -0.5 ± 0.7 kg/m2) compared with Control+ERGO (p < 0.05). No differences between groups were found in exercise induced changes in 6MWD and maximal exercise capacity. However, dyspnea after the 6MWT, HOMA-R, physical function and health perception domains of the CFQ14+ improved after NMES+ERGO compared with Control+ERGO (p < 0.05). Significant correlations were found between changes in mid-thigh circumference and muscle strength, ventilation requirements during exercise, insulin sensibility and the physical functioning section of CFQ14+ (p < 0.05). CONCLUSION: NMES training performed prior to endurance training is useful for strengthening peripheral muscles which in turn may augment gains in bodyweight and quality of life, further reductions in ventilation requirements during exercise and retard insulin resistance in CF patients with severe pulmonary obstruction.The study is registered with, number NCT003917031INSERM U 1042, HP2 Laboratory, Joseph Fourier University, Grenoble, France2Locomotion Rehabilitation and Physiology Department, Grenoble University Hospital, Grenoble, 38042, France3Inserm Clinical Research Center CIC03, Grenoble University Hospital, 38043 Grenoble, France4Cystic Fibrosis Center for Adults, Hospices Civils de Lyon, Claude Bernard University Lyon1, 69373 Lyon, France5Cystic Fibrosis Center for Adults, Pulmonology Department, Grenoble University Hospital, 38043 Grenoble, FranceCorresponding Author: Isabelle VIVODTZEV, Recherche sur l'Exercice, CHU de Grenoble, Hôpital Sud, Avenue Kimberley, 38 434 Echirolles, France
Isabelle Vivodtzev12; Nicolas Decorte12; Bernard Wuyam12; Nicolas Gonnet3; Isabelle Durieu4; Patrick Levy12; Jean-Luc Cracowski13; Claire Cracowski135
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  Chest     Volume:  -     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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