Document Detail

Benefits of the low pressure multichannel endotracheal ventilation.
MedLine Citation:
PMID:  8680704     Owner:  NLM     Status:  MEDLINE    
Mechanical ventilation using a modified endotracheal tube, allowing bypass and washout of the endotracheal dead space (McETV), was compared with conventional controlled mechanical ventilation (CMV) in healthy and in surfactant-depleted rabbits. In healthy animals, shifting from CMV to McETV led to an increase in PaO2 (89 +/- 16 versus 104 +/- 13 mm Hg; p < 0.05) and a decrease in PaCO2 (41.5 +/- 3 versus 30 +/- 3 mm Hg; p < 0.05). As a result of reducing the peak inspiratory pressure (PIP) from 21 +/- 2 to 12 +/- 2 cm H2O (p < 0.05), it was possible in McETV mode to maintain comparable ventilation to that achieved by CMV. In surfactant-depleted animals, compared with CMV, McETV produced a rise in PaO2 without change in thoracic volume (from 100 +/- 40 to 150 +/- 60 mm Hg, p < 0.05) and a fall in PaCO2 (from 46 +/- 5 to 37 +/- 4 mm Hg, p < 0.05). After 4 h of ventilation, the surfactant-depleted animals from the CMV group developed thoracic overdistension quicker (at hour 1, p < 0.05) and, consequently, more animals died from pneumothorax compared with the McETV group (five versus two). We concluded that McETV ensured adequate gas exchanges with lower insufflation pressures and could diminish positive pressure ventilation-induced injury.
D Pinquier; D Pavlovic; G Boussignac; M Aubier; F Beaufils
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  154     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-19     Completed Date:  1996-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  82-90     Citation Subset:  AIM; IM    
Service de Réanimation Pédiatrique, Hopital Robert Debré, Paris, France.
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MeSH Terms
Carbon Dioxide / blood
Intubation, Intratracheal / instrumentation
Oxygen / blood
Pulmonary Surfactants / physiology
Respiration, Artificial / instrumentation,  methods*
Respiratory Mechanics
Reg. No./Substance:
0/Pulmonary Surfactants; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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