| Benefits of the low pressure multichannel endotracheal ventilation. | |
| | |
MedLine Citation:
|
PMID: 8680704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mechanical ventilation using a modified endotracheal tube, allowing bypass and washout of the endotracheal dead space (McETV), was compared with conventional controlled mechanical ventilation (CMV) in healthy and in surfactant-depleted rabbits. In healthy animals, shifting from CMV to McETV led to an increase in PaO2 (89 +/- 16 versus 104 +/- 13 mm Hg; p < 0.05) and a decrease in PaCO2 (41.5 +/- 3 versus 30 +/- 3 mm Hg; p < 0.05). As a result of reducing the peak inspiratory pressure (PIP) from 21 +/- 2 to 12 +/- 2 cm H2O (p < 0.05), it was possible in McETV mode to maintain comparable ventilation to that achieved by CMV. In surfactant-depleted animals, compared with CMV, McETV produced a rise in PaO2 without change in thoracic volume (from 100 +/- 40 to 150 +/- 60 mm Hg, p < 0.05) and a fall in PaCO2 (from 46 +/- 5 to 37 +/- 4 mm Hg, p < 0.05). After 4 h of ventilation, the surfactant-depleted animals from the CMV group developed thoracic overdistension quicker (at hour 1, p < 0.05) and, consequently, more animals died from pneumothorax compared with the McETV group (five versus two). We concluded that McETV ensured adequate gas exchanges with lower insufflation pressures and could diminish positive pressure ventilation-induced injury. |
| | |
Authors:
|
D Pinquier; D Pavlovic; G Boussignac; M Aubier; F Beaufils |
Related Documents
:
|
8442604 - Treatment responses to surfactants containing natural surfactant proteins in preterm ra... 1174314 - Hyperbaric oxygen and pulmonary surface tension. 20874224 - Pilot study of vaporization of perfluorohexane during high-frequency oscillatory ventil... 8863244 - Surfactant rescue in the fetal lamb model of congenital diaphragmatic hernia. 19864004 - Effect of sustained hydrostatic pressure on rat bladder smooth muscle cell function. 23687634 - Waiting to inhale: an exploratory review of conditions that may predispose to pulmonary... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 154 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1996 Jul |
Date Detail:
|
Created Date: 1996-08-19 Completed Date: 1996-08-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 82-90 Citation Subset: AIM; IM |
Affiliation:
|
Service de Réanimation Pédiatrique, Hopital Robert Debré, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carbon Dioxide / blood Intubation, Intratracheal / instrumentation Oxygen / blood Pulmonary Surfactants / physiology Rabbits Respiration, Artificial / instrumentation, methods* Respiratory Mechanics |
| Chemical | |
Reg. No./Substance:
|
0/Pulmonary Surfactants; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in the inflammatory response of the lung during acute respiratory distress syndrome: prognos...
Next Document: Effect of ventilator-associated pneumonia on mortality and morbidity.