| Benefits of late coronary artery reperfusion on infarct expansion progressively diminish over time: relation to viable islets of myocytes within the scar. | |
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MedLine Citation:
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PMID: 8604623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To define the time limit and mechanism of the effects of late coronary artery reperfusion on infarct expansion, rats were randomized into one of four groups: permanent left coronary artery occlusion; and 2, 8, and 16 hours of left coronary artery occlusion followed by reperfusion. Two weeks after coronary occlusion, morphometric and histologic analyses were performed. Benefits of late reperfusion on infarct expansion progressively diminished after increasingly long periods of coronary occlusion and were minimal but present after 16 hours of coronary occlusion. The extent of the benefits of late reperfusion on infarct expansion were related to preservation and hypertrophy of small islets of still viable myocytes located mainly in the subepicardium of the scar. |
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Authors:
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I A Alhaddad; R A Kloner; I Hakim; J L Garno; E J Brown |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 131 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-05-15 Completed Date: 1996-05-15 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 451-7 Citation Subset: AIM; IM |
Affiliation:
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Cardiology Division, Department of Medicine, Nassau County Medical Center, Bronx, New York 10457, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Cell Survival Cicatrix / pathology*, surgery Coronary Disease / pathology, surgery Disease Models, Animal Female Linear Models Myocardial Infarction / pathology*, surgery Myocardial Reperfusion* Myocardium / pathology Random Allocation Rats Rats, Sprague-Dawley |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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